Aims Optimal antithrombotic therapy after percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI) and atrial fibrillation is uncertain. In this study, we compared antithrombotic regimes with regard to a composite cardiovascular outcome of all-cause mortality, MI or ischaemic stroke, and major bleeds. Methods and results Patients between October 2005 and December 2...

IMPORTANCE Medicare expenditures continue to grow rapidly, but the reasons are uncertain. OBJECTIVE To compare expenditures from 1998 through 1999 and 2008 for Medicare beneficiaries hospitalized for acute myocardial infarction (AMI). DESIGN, SETTING, AND PARTICIPANTS Cross-sectional analysis of a random 20% sample of fee-for-service Medicare beneficiaries admitted with AMI from 1998 throug...

INTRODUC~ON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 Materialsandmethods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 Percentage mortalities due to varying numbers of bacteria.. . . . . . . . . . . . . . . . . . . . . . . . ....

Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation of PTEN in mouse gastric epithelium initiates spontaneous carcinogenesis with complete penetrance by 2 months of age. Mechanistically, activation of Akt suppresses the abundance of p53...

Clinical pregnancies increasingly end in recurrent miscarriage (RM) during the first trimester, with genetic factors shouldering the main responsibility. MicroRNAs (miRNAs) regulate gene expression in a wide array of important biological processes. We examined the potential role of dysregulated miRNAs in RM pathogenesis and trophoblast development as an approach to elucidate the molecular mecha...

Chandra ACIS observations of PKS 0521−365 find that the X-ray emission of this BL Lac object consists of emission from an unresolved core, a diffuse halo, and a 2 arcsec jet feature coincident with the inner radio/optical jet. A comparison with a new ATCA 8.6-GHz map also finds X-ray emission from the bright hotspot southeast of the nucleus. The jet spectrum, from radio to X-ray, is probably sy...

References http://rstb.royalsocietypublishing.org/content/365/1548/1867.full.html#ref-list-1 This article cites 15 articles Rapid response http://rstb.royalsocietypublishing.org/letters/submit/royptb;365/1548/1867 Respond to this article Subject collections (271 articles) health and disease and epidemiology (1681 articles) evolution (1436 articles) ecology Articles on similar topics can b...

Direct and maternal genetic and environmental variances and covariances were estimated for weaning weight and growth and maturing traits derived from the Brody growth curve. Data consisted of field records of weight measurements of 3,044 Angus cows and 29,943 weaning weight records of both sexes. Growth traits included weights and growth rates at 365 and 550 d, respectively. Maturing traits inc...