Background. 8-Prenylnaringenin (8-PN) is the phytoestrogen with the highest affinity for estrogen receptor-α (ER-α), which is required to maintain BMD. The osteoprotective properties of 8-PN have been demonstrated previously in tibiae. We used a rat osteopenia model to perform the first investigation of 8-PN with whole-body vertical vibration (WBVV). Study Design. Ovariectomy was performed on 5...

Oral absorption of a drug is modeled by the differential equations for dissolution, permeation and gastrointestinal transit processes. The purpose of the present study was to compare simple approximate analytical solutions with full numerical solutions for the calculation of the fraction of a dose absorbed (Fa). The GI compartment model for numerical integration consisted of 1 stomach, 7 intest...

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The stellar population stripped from galaxies in clusters evolve under the extreme conditions imposed by the intracluster (IC) medium. Intracluster stars generally suffer very high systemic velocities, and evolve within a rarefied and extremely hot IC medium. We present numerical simulations which aim to explore the evolution and survival of IC Asymptotic Giant Branch (AGB) envelopes and Planet...

Protease nexin-2/amyloid 6 protein precursor (PN-2/A#PP) is an abundant, secreted platelet protein which is a potent inhibitor of coagulation Factor XIa. We examined other potential anticoagulant activities of PN-2/Ai8PP. Purified Kunitz protease inhibitor domain of PN-2/A8PP and PN-2/ABPP itself were found to prolong the coagulation time of plasma and pure Factor IXa. The Kunitz protease inhib...

Prurigo nodularis (PN) is an understudied inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules. Unfortunately, current treatments are often inadequate and there no FDA-approved therapies. PN also disproportionately affects black patients, who experience more fibrotic nodules suffer from increased systemic inflammation, comorbidity development, mortality. However...

Peripheral neuropathy (PN) caused by bortezomib is an important complication of multiple myeloma. Subcutaneous injection of bortezomib reduced PN, but 24% of cases were grade 2 PN and 6% of cases were grade 3 PN. PN higher than grade 2 was not resolved by subcutaneous injection. PN higher than grade 3 has serious dose limiting toxicity and is the cause of discontinuing bortezomib treatment. Laf...

Previous studies have reported that ultrafine bubbles (UFBs) can promote plant growth. However, the optimum application of UFBs has not been sufficiently clarified yet. In this study, we investigated UFB content index for lettuce cultivation. Content (CI) was defined as product pass numbers (Pn) and dilution ratio (D) taken to be indicative density; where Pn number times water passed through ge...

four new complexes of the type [lco ((do)(doh) pn) cl] pf , where (do) (doh) pn = n , n '- propanediylbis (2, 3-butanedione2-imine3-oxirne)a nd l =morpholine (mrpln) (i), benzylamine (bzlan) (ii), piperidine (pprdn)(iii) and pyrrolidine (prldn) (iv) have been synthesized and characterized by elemental analyses and spectroscopic methods. approximate values of the angular-overlap parameter, ...