Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques...

were isolated from the roots of Verbascum lasianthum Boiss. ex Bentham. In addition, 2 phenylethanoid glycosides, verbascoside {=acteoside, [β-(3,4-dihydroxyphenyl)-ethyl]-(3′-O-α-L-rhamnopyranosyl)-(4′ O-caffeoyl)-β-D-glucopyranoside} (4) and poliumoside {= [β-(3,4-dihydroxyphenyl)-ethyl]-(3′,6′-O-αL-dirhamnopyranosyl)-(4′ -O-caffeoyl)-β-D-glucopyranoside} (5), were also isolated. The structur...

Abstract C 13 H 20 O 4 , monoclinic, P 2 1 (no. 4), a = 9.7071(4) Å, b 7.9026(4) c 17.3139(7) β 101.617(4)°, V 1300.97(10) Å 3 Z 4, R gt (F) 0.0428, wR ref ( F ) 0.1145, T 170 K.

Three new diarylheptanoids, (3S,5R)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6E-heptene (1), (3S,5S)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6E-heptene (2), and (3S)-3-hydroxy-1,7-bis(4-hydroxyphenyl)-6E-hepten-5-one (3), four new flavonoid glycosides, 3,7,3'-tri-O-methylquercetin-4'-O-β-d-apiofuranosyl-(1→2)-O-β-d-glucopyranoside (4), 7,3'-di-O-methylquercetin-4'-O-β-d-glucopyranosyl-...

The α(6)β(4) integrin promotes carcinoma invasion through its ability to promote directed migration and polarization of carcinoma cells. In this study, we explore how the α(6)β(4) integrin cooperates with lysophosphatidic acid (LPA) to activate Rho and Rac small GTPases. Through the use of dominant negative Rho constructs, C3 exotransferase, and Rho kinase inhibitor, we find that Rho is critica...

Abstract A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The reaction between β-aryl/heteroaryl substituted nitroalkanes glyoxylate imine provides β-nitro-amines with good selectivity (70:30 >95:5) syn, anti-diastereoisomers. Reductive cyclisation BF3.OEt2...

We study the complexity of β-reduction for redexes of order 2, 3 and 4. The obtained results are: evaluation of boolean expressions can be reduced to β-reduction of order 2 and β-reduction of order 2 is in O(n log n), β-reduction of order 3 is complete for PTIME, and β-reduction of order 4 is complete for PSPACE.