The status of hepatic function can be altered by diverse influences. Multiple functional processes are measurably affected by several extrinsic toxic agents (typhoid toxin, chloroform, yellow phosphorus) as well as by a large number of pathological disorders. After exposure to toxins, in obstructive jaundice, in cirrhotic processes, in intrahepatic tumors and the like, either anatomical disrupt...

The reaction of 4-hydroxycoumarin (1) with some primary amines 2a-h and morpholine (2i) under microwave irradiation occurred without opening of the lactone ring to give N-substituted 4-aminocoumarins 3a-i in excellent yields. Under the same experimental conditions, 4-hydroxy-6-methyl-2-pyrone (4) reacted with benzylamine (2e) or 2-phenyl- ethylamine (2f) to give the corresponding N,N'-disubstit...

The regulation of protein synthesis is vital for a host of cell biological processes, but investigating roles for protein synthesis have been hindered by the inability to selectively interfere with it. To inhibit protein synthesis with spatial and temporal control, we have developed a photo-releasable anisomycin compound, N-([6-bromo-7-hydroxycoumarin-4-yl]methyloxycarbonyl)anisomycin (Bhc-Anis...

The status of hepatic function can be altered by diverse influences. Multiple functional processes are measurably affected by several extrinsic toxic agents (typhoid toxin, chloroform, yellow phosphorus) as well as by a large number of pathological disorders. After exposure to toxins, in obstructive jaundice, in cirrhotic processes, in intrahepatic tumors and the like, either anatomical disrupt...

The pharmacokinetics of ethoxycoumarin have been characterized using steady-state plasma concentrations achieved after administration of this compound, at a series of infusion rates, into the hepatic portal vein of rats. The clearance of ethoxycoumarin could be described by a one-site Michaelis-Menten kinetic model with Vmax and unbound KM values of 495 nmol/min/standard rat weight (SRW) and 3....

The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesi...