A generalized triangle group is a group that can be presented in the form G = 〈 x, y | x = y = w(x, y) = 1 〉 where p, q, r ≥ 2 and w(x, y) is an element of the free product 〈 x, y | x = y = 1 〉 involving both x and y. Rosenberger has conjectured that every generalized triangle group G satisfies the Tits alternative. It is known that the conjecture holds except possibly when the triple (p, q, r)...

OBJECTIVE The shortest pen needle (PN) for subcutaneous insulin therapy is 4 mm. Clinicians may hesitate to use it in obese patients. We report a post hoc analysis of a previously published study of the 4 mm × 32 G PN, evaluating responses in obese (≥30 kg/m(2)) and non-obese (<30 kg/m(2)). METHODS Subjects (BMI 20 to 49 kg/m(2), 52% obese) with diabetes used 4 mm × 32 G PNs and either 5 mm o...

An extensive network of transverse and longitudinal filamentous bridges was revealed when small myofibril bundles, prepared from Triton-EGTA-treated rabbit skeletal muscles, were extracted with KI to remove the majority of thin and thick filaments. Transmission and scanning electron microscopic studies of these salt-resistant cytoskeletal residues indicated: (a) small bundles of short transvers...

Goldberg (1972) has postulated the presence of specific dopamine receptors in renal and mnesenteric vascular smooth muscle. There is also some evidence that such receptors may also play a role in the coronary dilator effects of dopamine (Schuelke, Mark, Schmid & Eckstein, 1971; Toda & Goldberg, 1975). We have examined this possibility by comparing the effects of dopamine, dobutamine, noradrenal...

The membrane excitability and contraction were examined in single barnacle muscle fibers with different internal Ca(++) concentrations by using buffer solutions made up with EGTA and Ca-gluconate in various proportions. During the passage of dc currents the membrane shows all-or-none spike potentials for internal Ca(++) concentrations below about 8 x 10(-8)M, oscillatory potential changes in th...

In the present study, we developed a liquid chromatography-diode array detector-electrospray ionization/mass spectrometric (LC-DAD-ESI/MS) method for analysis of saikosaponins in Bupleurum falcatum. The LC method employed a ZORBAX SB-Aq analytical column (150 x 4.6 mm i.d., 5 μm) at a flow rate of 0.8 mL/min coupled with a diode array detector at 204 nm. A step gradient of acetonitrile-water (v...

Incubation of purified human 82-microglobulin (B2-m) with tissue transglutaminase (Tgase) resulted in the formation of high molecular weight polymers revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. In the presence of 30 mM ['4C]methylamine, the polymer formation was prevented, but incorporation of methylamine into ,8 2-m (equal to 1 methylamine per 1 molecule) could be ob...

PURPOSE To assess the effect of prostaglandin (PG) F2alpha and PGE1 on flow through the trabecular meshwork in organ preserved human anterior segments. METHODS Isolated human anterior segments were perfused under standard conditions at a constant pressure of 10 mm Hg, while flow was continuously monitored. After a stabilization period, 6 consecutive concentrations of PGs were administered. cA...

The effect of verapamil on K-stimulated 45Ca uptake (the difference between uptake in 60 mM-Ko medium and 5 mM-Ko medium) was studied using a synaptosomal fraction from rat brain. Verapamil inhibited K-stimulated 45Ca uptake, but not 45Ca uptake in 5 mM-Ko media (1 mM- and 0.1 mM-Cao media). The concentrations of verapamil inducing 50% inhibition of K-stimulated 45Ca uptake (ID50) in 1 mM- and ...