Background: Targeted agents present with a new spectrum of side-effects, including toxicities that negatively impact the risk of atherosclerosis. The aim of the present study was to evaluate the effect of the combination of targeted therapy and chemotherapy on serum homocysteine and other laboratory parameters of cardiovascular risk in patients with metastatic colorectal carcinoma. Patients and...

Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. The biotransformation of oxaliplatin is non-enzymatic and complexes with water, chloride, glutathione and methionine have been reported to be present in plasma ultrafiltrate from patients. Oxaliplatin gives rise to DN...

Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leucovorin; iii) 5fluorouracil + levamisole; iv) irinotecan; v) docetaxel + irinote...

carcinoma. Urol Clin North Am 2010; 37: 467–474. 136. Hussein AM, Benedetto P, Sridhar KS. Chemotherapy with cisplatin and 5fluorouracil for penile and urethral squamous cell carcinomas. Cancer 1990; 65: 433–438. 137. Shammas FV, Ous S, Fossa SD. Cisplatin and 5-fluorouracil in advanced cancer of the penis. J Urol 1992; 147: 630–632. 138. Di Lorenzo G, Buonerba C, Federico P et al. Cisplatin an...

Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs). This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 and IL-1, which stimulate CSCs, and also to its effects at multiple sites along CSC pathways, such as Wnt, Notch, Hedgehog and FAK. In spite of its multiple actions targeting CSCs, curcumin has little toxicity a...

Using preclinical models of human colon adenocarcinomas in immunedeprived mice, the influence of dose of [6#5]leucovorin ([6RS]LV, 20 to 1000 mjj/iir) administered by 24-h i.v. infusion was determined on the following parameters: (a) plasma concentrations of the active [6S] and inactive \6R] isomers of [6/?5]LV and the biologically active diastereoisomer of 5-methyltetrahydrolate (5-CH3-H4PteGl...

Dear Editor, Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types (osteoblasts, chondrocytes, myocytes and adipocytes). MSCs are found in bone marrow, adipose fat tissue, umbilical cord, dental pulp and other tissues [for review, see]. They are able to regenerate different damaged tissues. There is an intensive research of the use of MS...

The widespread introduction of high throughput RNA interference screening technology has revealed tumour drug sensitivity pathways to common cytotoxics such as paclitaxel, doxorubicin and 5fluorouracil, targeted agents such as trastuzumab and inhibitors of AKT and Poly(ADP-ribose) polymerase (PARP) as well as endocrine therapies such as tamoxifen. Given the limited power of microarray signature...

superficial dermis with occasional melanophages (Figure 3). The patient continued to receive cycles of chemotherapy, with no observed increase in pigmentation, until completing the treatment after 11 infusions. Five months after the last cycle of chemotherapy and 8 months after the appearance of the hyperpigmentation, no pigmentation was seen on the palms of the hands, and the reticular pigment...

,, background, medical treatment+ NB-UVB phototherapy is a very important modality in treating vitiligo but the treatment course usually exceeds 1 year. Different corrective surgical methods have evolved during the last four decades. various techniques of vitiligo surgery have been improvised and modified to achieve better results Some of these are: mini punch grafting,basal cell layer suspensi...