Background: This study investigated the effect of a mixture Gastrodiae elata and Glycyrrhizae uralensis (GGW) on β-amyloid-induced neuronal damage in vitro. Methods: For finding appropriate GGW ratio, we performed MTT assays using ratios 5:5, 6:4, 7:3, 8:2 9:1 SK-N-SH cell SH-SY-5Y cell. Treatment with β-amyloid (10 μM) caused death overexpression acetylcholinesterase (ACHE) cells. treatment in...

A number of neural and nonneural tumor cell lines of rat and human origin were assayed for neuron-specific enolase (NSE) by radioimmunoassay. Most neural tumor cell lines had appreciably higher levels of NSE than did the nonneural tumor cell lines, the highest levels being found in two anaplastic rat glioma lines ( F98 and T24). These two lines contained more than twice the amount of NSE found ...

While arsenic compounds are known as environmental toxicants (especially in drinking water) and as carcinogens, some arsenic compounds, like arsenic trioxide (As2O3), are clinically used in humans to treat some forms of cancer (e.g. leukemia). Although arsenic compounds have been studied intensively, their interactions with living cells are still not fully elucidated. We have previously propose...

PURPOSE The use of replication-selective oncolytic adenoviruses is an emerging therapeutic approach for cancer, which thus far has not been employed for carcinoids. We therefore constructed Ad[CgA-E1A], a novel replication-selective oncolytic adenovirus, where the chromogranin A (CgA) promoter controls expression of the adenoviral E1A gene. EXPERIMENTAL DESIGN The Ad[CgA-E1A] virus was evalua...

Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown. One possibility, demonstrated in peripheral tissue cell lines, is that apoE stimulates nitric oxide synthase (NOS) via a receptor-dependent signalling pathway and that apoE4 generates inappropriate amounts of nitric oxide (NO) comp...

The incidence of type 1 diabetes mellitus (T1DM) is rising rapidly in children, with an overall annual global increase of 3%. Approximately 79,100 children under age 15 develop T1DM annually. Although the reported incidence of T1DM in China was as low as 0.6 per 100,000 per annum in 1995, the number of children with T1DM cannot be underestimated within the large population. The number of type 2...

Materials and methods We have administrated in 291 adolescents with Idiopathic Adolescents Scoliosis, the BBS questionnaire, adding one more question. The added question was “if I believe that the brace can change the image that my school friends have for me”. We have divided in two groups 219 girls and 72 boys. The average age was 14, 5y and the Cobb angle was from 19 to 64 and the Surface Rot...

Alzheimer's disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a...