As an extended period of unusually dry weather conditions without sufficient rain, drought poses enormous risk on societies. Characterized by the absence precipitation for long periods time, often resulting in water scarcity, droughts are increasingly posing significant environmental challenges. Drought is therefore considered important element management resources, especially groundwater resou...

During systemic inflammation, the liver becomes unresponsive to growth hormone (GH), resulting in decreased plasma insulin-like growth factor-I (IGF-I) with concomitant reductions in lean body mass. Transgenic mice that overexpress IL-6 also demonstrate impaired growth and decreased IGF-I. To determine whether IL-6 directly inhibits GH-inducible gene expression, CWSV-1 hepatocytes were incubate...

In both rodents and humans, excessive consumption of a typical Western diet high in saturated fats and cholesterol is known to result in disruption of energy metabolism and development of obesity and insulin resistance. However, how these high-fat, energy-dense diets affect bone development, morphology, and modeling is poorly understood. Here we show that male weanling rats fed a high-fat (HF) ...

Virulence genes located on pathogenicity islands play a crucial role in the pathogenesis of Salmonella enterica infections. Salmonella pathogenicity islands (SPI) contribute to host cell invasion and intracellular pathogenesis. At present, 12 SPI have been described. Although size, structure and function of these SPI, as well as the distribution in Salmonella subspecies and serovars can be mark...

Two deletion-substitution mutations of phage lambda, spi-113 and spi-274, are shown to remove about half of the rightward operator OR. Physiological studies show that spi-113 is still repressible. Thus, the 50 or so nucleotides of OR deleted in this mutant are not absolutely essential for repression. prm-116, which inactivates the promoter essential for the maintenance of lambda repressor synth...

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major intestinal pathogen of both humans and animals. Salmonella pathogenicity island 1 (SPI-1)-encoded virulence genes are required for S. Typhimurium invasion. While oxygen (O2) limitation is an important signal for SPI-1 induction under host conditions, how the signal is received and integrated to the central SPI-1 regulatory syst...

BACKGROUND Determination of relationships between transcranial Doppler (TCD)-based spectral pulsatility index (sPI) and pulse amplitude (AMP) of intracranial pressure (ICP) in 2 groups of severe traumatic brain injury (TBI) patients (a) displaying plateau waves and (b) with unstable mean arterial pressure (MAP). METHODS We retrospectively reviewed patients with severe TBI and continuous TCD m...

OBJECTIVES To identify the critical dimensions of hospital Chief Executive Officers' (CEOs) involvement in a quality and safety and to offer practical guidance to assist CEOs to fulfil their leadership role in quality improvement (QI). DESIGN Qualitative interview study. SETTING 20 organisations participating in the main phase of the Safer Patients Initiative (SPI) programme across the UK. ...

Through this article we intent to demonstrate how a qualification and certification program, like CertiBPM, developed and implemented with the support of European Certification and Qualification Association (ECQA), can be use to better support the SPI efforts and strategies into Romanian companies. The research results show only the preliminary opinions (collected through the trainees/employees...