AIM To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance. METHODS In a sequentially assigned crossover treatment study, pregnant women with uncomplicated falciparum malaria received i.v. artesunate (i.v. ARS) (4mgkg(-1) ) on the first day and ora...

A percepção dolorosa, avaliada funcionalmente através do sistema analgésico endógeno, reflete a atividade nociceptivo, o qual depende nível de excitabilidade nervoso, portanto, procura vias e formas que reduzam deste tornou-se uma preocupação humana para assim aliviar da dor. Objetivo: Determinar limiar excitação nociceptivo em animais (camundongos) submetidos tratamento com diferentes doses cl...

Channel catfish Ictalurus punctatus fingerlings were fed purified diets supplemented with iron at levels of 0, 20, 60, and 180 mgkg from iron sulfate (FeS) or 5, 10, 20, 60, and 180 mgkg from iron methionine (FeM) in triplicate tanks for 8 wk. Fish were then divided into two groups and subjected to different assays to measure disease resistance and individual immune functions. Representative fi...

Medicinal plants may provide valuable therapeutic agents in modern medicine and traditional system, especially areas where the drugs are unavailable, expensive or predispose to life threatening complications. One of these is Garlic (Allium L. liliaceae) which used as foodstuff, condiment, flavoring folk medicine. The aim this study was investigate effect garlic juice on plasma glucose concentra...

Aims: This study was aimed at investigating the protective potential of ethyl acetate fractions Persea americana (PA) seed and Bryophyllum pinnatum (BP) leaf binary combinations against indomethacin-induced gastric ulcers.
 Methodology: Fifty (50) male Wistar rats were used in this study; they assigned into 10 groups five animals each respective received a standard rat diet drinking water ...

ascorbic acid (vitamin c) supplementation has been documented as a useful tool to improve the performance of laying birds reared under harsh environmental conditions. however, there is limited information on the use of ascorbic acid as a means of ameliorating the stressful conditions imposed by feed restriction. to this effect a 3 × 2 factorial experiment was carried out to evaluate the effect ...

effects of chromium nano particles (nanocr) on performance and meat quality of japanese quail under physiological stress was determined by  using 360 birds in a completely randomized design with six treatments, four replicates and 15 birds per each, during  17- 35 d of age. the tratments were negative control (non-stressed), and five groups under physiological stress which fed on diets suppleme...

Gibel carp (Carassius auratus gibelio) juveniles with an average weight of 8.73± 2.1 g were fed a basal diet (control) and three experimental diets (T200, T400 and T800), containing 200, 400 and 800 mgkg-1, respectively of thyme essential oil (Thymus vulgaris) for six weeks. After six weeks feeding trial, both control and thyme essential oil-added feed groups were exposed to sub-acute toxicity ...

For warm-blooded species, the hazardous dose of a chemical (HD50) is an upcoming and important characteristic in the assessment of toxic chemicals. Generally, experimental information is available for a limited number of warm-blooded species only, which causes statistical uncertainty. Furthermore, when small datasets contain an unrepresentative sample of species, they can cause systematic uncer...