نتایج جستجو برای: 6mevradiotherapy hyperthermia goldnanopaticles radiosensitization
تعداد نتایج: 10517 فیلتر نتایج به سال:
Paclitaxel is a deterpene with antitumor activity against a variety of human neoplasms. Paclitaxel cytotoxicity is thought to derive mainly from a stabilization of microtubules as a result of enhanced tubulin polymerization that leads to an accumulation of cells in the mitotic (M) phase of the cell cycle. Because cells in this phase of the cell cycle are known to be radiosensitive, it was thoug...
Melanoma is an aggressive malignancy that is increasingly common and exhibits a poor patient survival rate. Radiotherapy is the primary option for patients with melanoma, particularly those who are not candidates for surgery; however, the therapeutic effect is limited due to the relative radioresistance of melanoma to ionizing radiation (IR). It has been reported that microRNAs (miRNAs) serve a...
MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work i...
Objective: Febrile seizures are the most common seizure disorder in childhood, and occur in 2-5% of children. While simple febrile seizures are frequently described as inoffensive disorder there are evidence suggesting the association between simple febrile seizures and hippocampal abnormalities in adulthood. This study was designed to evaluate the protein levels of Bcl-2 and Bax in the rat neo...
Due to importance of combination therapies in cancer treatment, this study was performed to find the effects of hyperthermia and neutron irradiation and heir combination on the human lymphocytes. Blood samples were treated separately with 41.5 °C for 30 and 60 minutes, 43 °C for 15 and 30 minutes, as well as 10 cGy neutron irradiation. They also treated with hyperthermia followed by irradiation...
In recent years, Hyperthermia has been used as an emerging technique for cancer treatment, especially for localized tumors. One of the promising cancer treatment approaches is magnetic nanoparticle (MNPs) Hyperthermia. In this theoretical work, the temperature distribution of a common tumor over the different sizes of Fe3O4 magnetic nanoparticles, namely 25, 50, 100, and 200 nm, was stud...
BACKGROUND This follow-up study aims to determine the physical parameters which govern the differential radiosensitization capacity of two tumor cell lines and one immortalized normal cell line to 1.9 nm gold nanoparticles. In addition to comparing the uptake potential, localization, and cytotoxicity of 1.9 nm gold nanoparticles, the current study also draws on comparisons between nanoparticle ...
Radiosensitization using gold nanoparticles (AuNPs) has been shown to vary widely with cell line, irradiation energy, AuNP size, concentration and intracellular localization. We developed a Monte Carlo-based AuNP radiosensitization predictive model (ARP), which takes into account the detailed energy deposition at the nano-scale. This model was compared to experimental cell survival and macrosco...
Concurrent treatment with the methylating agent temozolomide during radiotherapy has yielded the first significant improvement in the survival of adult glioblastomas (GBM) in the last three decades. However, improved survival is observed in a minority of patients, most frequently those whose tumors display CpG methylation of the O(6)-methylguanine (O(6)-meG)-DNA methyltransferase (MGMT) promote...
Introduction: hyperthermia using different methods such as microwave and magnetic waves is one of the methods to treat cancer. In this method, iron and magnetic nanoparticles are used to increase the temperature and increase the effect of hyperthermia as auxiliary treatment with chemotherapy and radiotherapy. In this study, the role of iron and magnetic nanoparticles have been ...
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