[structure: see text] UG forms a highly stable quadruply hydrogen-bonded heterocomplex with DAN, but the fidelity of the complex is lowered somewhat by the Hoogsteen-side oligomerization of UG (K(assoc) approximately 230 M(-)(1), CDCl(3)). DeUG was prepared as a more robust analogue of UG lacking the Hoogsteen nitrogen atom. Remarkably, the deaza analogue, DeUG, forms a much more stable complex...

BACKGROUND Readmission of mechanically ventilated patients to an ICU within 7 d reflects not only patient safety but also the quality of care of the ICU. This study aimed to investigate the risk and related factors for readmission to an ICU within 7 d in mechanically ventilated subjects. METHODS A total of 658,452 mechanically ventilated subjects discharged from an ICU whose age was ≥ 17 y ol...

Growth hormone (GH) use has been speculated to improve physical capacity in subjects without GH deficiency (GHD) through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect...

OBJECTIVE Insight into the long-term course of depression and anxiety. METHOD Data were derived from Netherlands Mental Health Survey and Incidence Study/Netherlands Study of Depression and Anxiety, epidemiologic surveys in the adult population in the Netherlands. Three hundred and three respondents with depressive and/or anxiety Composite International Diagnostic Interview (CIDI) disorder we...

PURPOSE Evaluation of age- and sex-specific differences of anthropometric parameters that were used as indicators of growth and nutritional status in children aged 6 and 7 years in R. Macedonia and their comparison with the WHO and NCHS reference values. MATERIAL AND METHODS The study included 580 children aged 6 to 7 years from different regions of R. Macedonia. Eighteen anthropometric param...

BACKGROUND Glucagon-like peptide-1 (GLP-1)(7-36) amide is an intestinal incretin hormone which also inhibits gastric acid secretion in humans. Its mechanism of action is unclear, but it strongly inhibits vagally induced secretion (sham feeding), suggesting that it could influence vagal activity. AIM/METHODS The effect of intravenous GLP-1 (7-36 amide) (1 pmol/kg/min) was studied on pentagastr...

Monaghan et al. (6 ) in a Scottish population. Our study provides similar findings in an Italian population, without any differences between regional origins. Moreover, 7 of 16 subjects with the 7/7 genotype had STB within the reference interval. These data, in agreement with the recent study by Rudenski and Halsall (7 ), confirm that the Gilbert genotype is not always expressed. There is a nee...

A family with an insertional type of chromosome rearrangement involving chromosomes 7 and 13 is reported. An interstitial deletion of a segment of chromosome 7 (7q32 leads to 34) had been inserted into the long arm of chromosome 13 at breakpoint q32. Segregation of this chromosome rearrangement gave rise to three subjects who were monosomic for the involved segment of chromosome 7. The karyotyp...

BACKGROUND The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to AC...