Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by several members of the poxvirus family, including vaccinia, variola, and monkeyp...

BACKGROUND The number of nurses able to independently prescribe medicines in England has risen steadily in recent years. AIM To evaluate the adequacy of nurses' educational preparation for independent prescribing and to describe nurses' experiences of their continuing professional development as prescribers in practice. DESIGN AND METHOD Postal questionnaire survey. PARTICIPANTS Random sa...

Let’s begin by briefly reviewing the Matlab routines required for VQ-based image compression. First, note that the VQ parameters are set on lines 13-19 of prob1.m. The general VQ framework is implemented by learnVQ.m, which uses the subroutine kmeans.m to implement the k-means algorithm. (Note that, as recommended, we use findnn.m and lpnorm.m within the k-means implementation to allow flexible...

Heusler materials have attracted a large amount of attention in the development of spintronic technologies. In this issue, Wang et al. [IUCrJ (2017), 4, 758-768] show how strain can be used to tune the band structure of these materials.

We assessed the utility of fluorescent in situ hybridization (FISH) in the screening of clone libraries of (meta)genomic or environmental DNA for the presence and expression of bacterial ribosomal RNA (rRNA) genes. To establish proof-of-principle, we constructed a fosmid-based library in Escherichia coli of large-sized genomic DNA fragments of the mycophagous soil bacterium Collimonas fungivora...

Orthopoxviruses, such as variola and monkeypox viruses, can cause severe disease in humans when delivered by the aerosol route, and thus represent significant threats to both military and civilian populations. Currently, there are no antiviral therapies approved by the U.S. Food and Drug Administration (FDA) to treat smallpox or monkeypox infection. In this study, we showed that administration ...