introduction: trastuzumab is a monoclonal antibody that is used in treating breast cancer. we labeled this monoclonal antibody with technetium-99m and performed in vitro and in vivo quality control tests as a first step in the production of a new radiopharmaceutical. methods: trastuzumab was labeled with technetium-99m using succinimidyl hydrazinonicotinamide (hynic) as chelator. radiochemical ...

[3H]Proline and [3H]uridine were injected into both eyes of the goldfish. 1 h before and after this injection 3X10)-6)M ouabain was administrated unilaterally to the retina. 8 h and 24 h after tracer injection the radioactivity in the retina, optic nerve and tectum was measured. It is suggested that the inhibition of the neuronal Na+-K+-ATPase inside the retina is responsible for the reduction ...

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

This study was designed to examine the effects of intracerebroventricular (ICV) injection of ketanserin(5-HT2a receptor antagonist) and SB242084 (5-HT2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. In experiment 1, birds were injec...

Introduction: The optimal imaging time of a radionuclide scintigraphy is the time at which the organ of interest has the maximum uptake of the injected radionuclide. This study was performed to investigate the maximum uptake time of 99mTc-DMSA in rat renal scan. Methods: Renal scintigraphy was performed with 3 mCi of 99mTc-DMSA. Planar images were acquired every 20 minutes for 8 hours post-inje...

introduction: adequate pain control is an important consideration in the post-surgical management of patients. local nerve blockade added to general anesthesia can provide excellent pain control during and after most nasal surgical procedures. the aim of this study was to determine the combined effect of local anesthetic drugs with corticosteroids in nasal surgery. materials and methods: in thi...

The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...

in-vitro labeling of rbc with 99mtc is an intricate procedure and there is always a need foran alternate blood pool imaging agent. the aim of this study was to prepare an effective nanosized liposome (nls) similar to human rbc for blood pool scintigraphy. this study formulatespeg-nls and non-peg-nls using film method plus high pressure homogenization technique.biodistribution studies were perfo...

Potential hosts for infective juveniles of entomopathogenic nematodes can vary considerably in quality based on the characteristics of the host species/stage, physiological status (e.g. stress, feeding on toxins), and infection status (heterospecific or conspecific infection). In this study, we investigated responses of the entomopathogenic nematode Steinernema riobrave to hosts (Galleria mello...