OBJECTIVES To analyze the predictive values of selective venous sampling (SVS) in our own experience and in a systematic meta-analysis of the international literature and to compare them with the results of noninvasive localization studies before reoperative parathyroid surgery. DATA SOURCES Twenty-one consecutive patients with persistent or recurrent renal hyperparathyroidism underwent preop...

HYPOTHESIS High-resolution ultrasound and technetium Tc 99m sestamibi scanning can be used for preoperative localization of abnormal parathyroid glands in patients with hyperparathyroidism. DESIGN Ultrasound and sestamibi scanning were performed in patients undergoing neck exploration for hyperparathyroidism. If the 2 scans agreed in identifying a single adenoma, and surgery confirmed the loc...

INTRODUCTION Reperfusion therapy with either thrombolysis or angioplasty has been shown to be beneficial in acute myocardial infarction. Tc-99m sestamibi is a myocardial tracer that can be used to assess myocardial salvage because of its property of very limited redistribution. MATERIALS AND METHODS To assess the feasibility of this technique locally, Tc-99m sestamibi was injected before and ...

bone involvement. Destruction is mediated through normal osteoclasts, which respond to local osteoclast-activating microenvironment [7]. Technetium-99m 2methoxyisobutylisonitrile (TC-99m MIBI) is a lipophilic agent that accumulates within living malignant cells due to the higher transmembrane electrical potential as a consequence of the higher metabolic rate than in the surrounding normal cells...

BACKGROUND Low-dose dobutamine stress echocardiography is increasingly used for identifying myocardial viability. AIM We explored whether dobutamine-induced strain (S) and strain rate (SR) can identify myocardial viability following fibrinolytic therapy for ST-segment-elevation myocardial infarction (STEMI), taking (99m)Tc-sestamibi scintigraphy as the "gold standard" for diagnosis. METHODS...

UNLABELLED (99m)Tc-sestamibi dual-phase scintigraphy is currently established for parathyroid localization. However, the imaging technique is not standardized, and the role of the pinhole collimator, especially, is not fully recognized in the imaging protocol. The aim of this study was to check whether the use of a pinhole collimator in parathyroid scintigraphy would enhance lesion detectabilit...

OBJECTIVES The goal of this study was to examine the effect of acute beta-blockade on dipyridamole Tc-99m sestamibi myocardial perfusion imaging (DMPI). BACKGROUND Studies suggest that antianginal drugs may reduce the presence and severity of myocardial perfusion defects with dipyridamole stress. However, there are no data regarding specific drugs. METHODS Patients with catheterization-prov...

BACKGROUND The purpose of this retrospective investigation was to evaluate the results of preoperative localization studies and intraoperative parathyroid hormone (IOPTH) assay in patients with primary hyperparathyroidism and double adenomas. STUDY DESIGN Twenty-one of 287 consecutive patients with primary hyperparathyroidism who had double adenomas identified during first-time parathyroid ex...

PURPOSE P-glycoprotein (Pgp) antagonists have been difficult to develop because of complex pharmacokinetic interactions and a failure to show meaningful results. Here we report the results of a pharmacokinetic and pharmacodynamic trial using a third-generation, potent, noncompetitive inhibitor of Pgp, tariquidar (XR9576), in combination with docetaxel. EXPERIMENTAL DESIGN In the first treatme...