نتایج جستجو برای: abc transporter
تعداد نتایج: 61372 فیلتر نتایج به سال:
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer cells produce ATP mostly through glycolysis, in the present study we explored the effects of inhibiting glycolysis on the ABC transporter function and drug sensitivity of malignant cells. Inhibition of glycolysis by 3-bromopyr...
Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans Because several genes cod...
Till date the largest known family of transporters is ABC transporter superfamily. The genes that encode ABC genes are widely dispersed in genome and show a high degree of amino acid sequence identity among eukaryotes. Phylogenetic analysis has allowed the gene superfamily divided into seven subfamilies containing 49 members of proteins in human. Despite the immense amount of biochemical studie...
In addition to the ATP-binding cassette (ABC)-type nitrate/nitrite-bispecific transporter, which has a high affinity for both substrates (K(m), approximately 1 microM), Synechococcus elongatus has an active nitrite transport system with an apparent K(m) (NO(2)(-)) value of 20 microM. We found that this activity depends on the cynABD genes, which encode a putative cyanate (NCO(-)) ABC-type trans...
We performed classification and analysis of the eukaryotic ABC (ATP-Binding Cassette) transporters in S. cerevisiae, C. elegans, and D. melanogaster which are the three eukarya whose genomes were sequenced completely. The ABC transporters form a major class of active transporters which are widespread in archaea, bacteria, and eukarya. These transporters convey a wide variety of substrates, such...
The ATP-binding cassette (ABC) transporter GlnPQ is an essential uptake system for amino acids in gram-positive pathogens and related nonpathogenic bacteria. The transporter has tandem substrate-binding domains (SBDs) fused to each transmembrane domain, giving rise to four SBDs per functional transporter complex. We have determined the crystal structures and ligand-binding properties of the SBD...
Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pulmonary inflammation. Three ATP-binding cassette (ABC) transporters are found i...
In ticks, the digestion of blood occurs intracellularly and proteolytic digestion of hemoglobin takes place in a dedicated type of lysosome, the digest vesicle, followed by transfer of the heme moiety of hemoglobin to a specialized organelle that accumulates large heme aggregates, called hemosomes. In the present work, we studied the uptake of fluorescent metalloporphyrins, used as heme analogs...
Gout is a chronic arthritic disease associated with high levels of urate in blood. Recent advances in research have permitted the identification of several new and common genetic factors underlying the disease. Among them, a polymorphism in the ABC transporter gene ATP-binding cassette transporter isoform G2 has been highlighted. ATP-binding cassette transporter isoform G2 was found to be invol...
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