Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function of IORT. Materials and Methods: Six Breast Cancer (BC) patients as a pilo...

In conversations between native speakers, words such as ‘same’ and ‘identical’ do not usually cause much difficulty. We take it for granted that others use them with the same sense as we do. If it is unclear whether numerical or qualitative identity is intended, a brief gloss such as ‘one thing not two’ for the former or ‘exactly alike’ for the latter removes the unclarity. In this paper, numer...

Accuracy of the radiotherapy requires some routine quality control and dosimetry calculations, which would be done by radiotherapy physicists. Due to the increasing use of computers and simulation software in medical science, as well as trends indicating its continued growth, this study aims to develop a new smart-phone application to perform common radiotherapy-related calculations. Computatio...

BACKGROUND To analyse limits and capabilities in dose calculation of collapsed-cone-convolution (CCC) algorithm implemented in helical tomotherapy (HT) treatment planning system for thorax lesions. METHODS The agreement between measured and calculated dose was verified both in homogeneous (Cheese Phantom) and in a custom-made inhomogeneous phantom. The inhomogeneous phantom was employed to mi...

The Proton Therapy Center in Orsay (CPO) and CEA/DAPNIA launched the joint project on Monte Carlo modeling of a CPO beam line with the aim to achieve a prediction of dose distribution in all the calibration configurations (depth and the shape of the tumor) better than 2%. The calculation module is intended to be used for the absolute dosimetry of the clinical beam (patient Quality Assurance – Q...

A methodology for the dosimetric verification of micro-multileaf collimator MMLC) based intensity modulated radiation therapy (IMRT) plans intended for stereotactic applications is described. The procedure is similar to that of conventional IMRT patient-specific quality assurance with some notable exceptions. Relative dosimetry measurements are performed with radiographic film, a commercial fil...

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Isoniazid is the most widely used first line antituberculosis drug. It is considered safe during lactation, but limited data are available on the transfer of isoniazid from circulation to milk in lactating women, which can provide an assessment of extent of exposure to the nursling. WHAT THIS STUDY ADDS The study documents the transfer pattern and milk...

Intraoperative electron radiation therapy (IOERT) cannot usually benefit, as conventional external radiotherapy, from software systems of treatment planning based on computed tomography and from common dose verify procedures. For this reason, in vivo film dosimetry (IVFD) proves to be an effective methodology to evaluate the actual radiation dose delivered to the target. A practical method for ...

Fundamental notions concerning absolute structure and absolute configuration, and their determination from single-crystal diffraction measurements, are presented and reviewed. A glossary of terms with definitions useful in this field is provided. For absolute structure and its determination, the separate but interacting influences of the structure and the inversion-distinguishing power of an X-...