We previously found no significant differences in mortality between men who underwent surgery for localized prostate cancer and those who were treated with observation only. Uncertainty persists regarding nonfatal health outcomes and long-term mortality. From November 1994 through January 2002, we randomly assigned 731 men with localized prostate cancer to radical prostatectomy or observation. ...

OBJECTIVE To compare the trends in mortality inequalities by educational attainment with trends using area deprivation. SETTING Scotland and England & Wales (E&W). PARTICIPANTS All people resident in Scotland and E&W between 1981 and 2011 aged 35-79 years. PRIMARY OUTCOME MEASURES Absolute inequalities (measured using the Slope Index of Inequality (SII)) and relative inequalities (measure...

Male superiority in the field of spatial navigation has been reported upon, numerous times. Although there have been indications that men and women handle environmental navigation in different ways, with men preferring Euclidian navigation and women using mostly topographic techniques, we have found no reported links between those differences and the shortcomings of women on ground of ineffecti...

The aim of this study was to test the psychometric properties Adlerian Inferiority and Superiority Complex Shortened Scales in a Turkish sample. Exploratory factor analysis sample consisted 331 individuals (192 female 139 men) between ages 15 65, while confirmatory 192 (113 79 64. As result exploratory analysis, inferiority complex showed structure 10 items, superiority 9 items. Confirmatory th...

BACKGROUND An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a decade in England. METHODS We utilised the UK-based Clinical Practice Research Datalink to identify 9653 ...

OBJECTIVES To identify non-inferiority trials within a cohort where the experimental therapy is the same as the active control comparator but at a reduced intensity and determine if these non-inferiority trials of reduced intensity therapies have less favourable results than other non-inferiority trials in the cohort. Such a finding would provide suggestive evidence of biocreep in these trials....

OBJECTIVE To assess predictors of CVD mortality among men with and without diabetes and to assess the independent effect of diabetes on the risk of CVD death. RESEARCH DESIGN AND METHODS Participants in this cohort study were screened from 1973 to 1975; vital status has been ascertained over an average of 12 yr of follow-up (range 11-13 yr). Participants were 347,978 men aged 35-57 yr, screen...

PURPOSE To establish the concept of minimum clinically meaningful outcome (mCMO) of treatment in advanced solid tumors, to establish its threshold and evaluate how many superiority trials of new antineoplastic agents pass this threshold. EXPERIMENTAL DESIGN We chose overall survival as the primary indicator of patient benefit. Four conceptually different types of treatment effect can be ident...

Abstract The present research aimed to extend the state of knowledge regarding relationship between self-perceived empathy and traditional gender roles placed particular focus on contextual conditions under which differences in are present, can be created, or eliminated. Across two studies, women rated themselves higher than men all experimental conditions, whereas an objective female superiori...