drug administration. However, the barrier properties of the outermost layer, the stratum corneum, have limited the number of successful transdermal dosage forms developed thus far. One of the strategies for overcoming this problem is temporary local reduction of the barrier function of the stratum corneum with the aid of a percutaneous absorption enhancer. Sucrose fatty acid esters (sugar ester...

Myocyte enhancer factor-2-activating motif and SAP domain-containing transcriptional regulator (MAMSTR) regulates its downstream through binding in promoter regions. However, molecular mechanism, particularly the DNA-binding sites, coregulatory genes are quite unexplored. Therefore, to identify genome-wide sites of MAMSTR transcription factors their genes, chromatin immunoprecipitation sequenci...

BACKGROUND Our aim was to investigate the potential of the DustGun aerosol technology integrated with the isolated, perfused, and ventilated lung of the rat (IPL) to study the pulmonary disposition of an inhaled model biopharmaceutical, the 40-kDa protein horseradish peroxidase (HRP). METHOD The DustGun aerosol technology was used to deliver respirable powder aerosols of HRP (the mass median ...

gene therapy is in its development stage as a novel method for cancer treatment. liposomes look promising as gene delivery vectors; however, investigations have shown that these vesicles are not doing well in some cases. it was decided here to investigate the possibility of augmentation of liposomal gene delivery by chemical penetration enhancers.cationic liposome containing antisense oligonucl...

Abstract The multifunctionality of genome is suggested at some loci in different species but not well understood. Here we identified a DES-K16 region an intron the Kctd16 gene as chromatin highly marked with epigenetic modifications both enhancers (H3K4me1 and H3K27ac) silencers (H3K27me3) mouse spermatocytes. In vitro reporter assay demonstrated that exhibited significant enhancer activity spe...

OBJECTIVE To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN AND METHODS In this single-center open euglycemic glucose clamp study 13 hea...