The NMR characteristics of [14-38]Abu, a synthetic variant of BPTI that is partially folded in aqueous buffer near neutral pH, support a model of early folding events which begin with stabilization of the nativelike, slow exchange core [Barbar, E., Hare, M., Daragan, V., Barany, G., and Woodward, C. (1998) Biochemistry 37, 7822-7833 (1)]. In partially folded [14-38]Abu, urea denaturation profil...

To study the structural and functional roles of the cysteine residues at positions 36, 41, and 46 in the transmembrane domain of phospholamban (PLB), we have used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptide synthesis to prepare alpha-amino-n-butyric acid (Abu)-PLB, the analogue in which all three cysteine residues are replaced by Abu. Whereas previous studies have shown that repla...

During asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract for extended periods of time without causing symptoms of urinary tract infection. Previous studies indicate that many Escherichia coli (E. coli) strains that cause ABU have evolved from uropathogenic E. coli (UPEC) by reductive evolution and loss of the ability to express functional virulence factors. For instance, the p...

The antimicrobial activity of 8 Bacillus spp. and 2 Lysinibacillus spp. representing the predominant aerobic sporeformers during traditional maari fermentations, a traditional fermented baobab seeds product from Burkina Faso, was investigated. The antimicrobial activity was assessed against a total of 31 indicator organisms representing various Gram-negative and positive pathogens. The screenin...

Jason K. Sicklick, Yin-Xiong Li, Alaa Melhem, Eva Schmelzer, Marzena Zdanowicz, Jiawen Huang, Montserrat Caballero, Jeff H. Fair, John W. Ludlow, Randall E. McClelland, Lola M. Reid,* and Anna Mae Diehl* Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Division of Surgical Oncology, Department of Surgery, Johns Hopkins University Scho...

This research examines the nature of Int investigation shows that Internet-based sy business innovation and responsiveness. problems with the use of traditional meth change, as they are systematic, compreh the importance of modelling value-adde applications, as well as the need for selfthinking and self-reflection on the prob requirements modelling and design ‘P brainstorming sessions guided by...

Fung 11, Abu-Elmagd K, Todo S, Shapiro R, Tzakis A, Jordan M, Armitage J, Jain A, Martin M, Bronster 0, Stieber A, Kormos R, Selby R, Gordon R, Starzl TE. FK506 in clinical organ transplantation. John J. Fung, Kareem Abu-Elmagd, Saloro Todo, Ronald Shapiro, Andreas Tzakis, Mark Jordan, John Armitage, Ashok Jain, Maureen Martin, Oscar Bronster, Andrei Stieber, Robert Kormos, Robert Selby, Robert...

Studies show that the pH of the malaria parasite’s digestive vacuole (DV) plays a key role in the physiological functions of this organelle and antimalarial drug accumulation, and yet is technically difficult to measure. In this study, a flow cytometry-based technique was developed to measure the DV pH using a ratiometric pH indicator, FITC-dextran loaded into the DV of saponin-permeabilized pa...

The aim of this purpose was to compare injury mechanism in boys’ amateur epical athletes in Kyokushin, Karate and Aikido. 95 Aikido athletes, 83 Kyokushin ka athletes, 76 Karate ka were randomly selected from Shiraz clubs. Data were analyzed by Χ test. The results showed that the rate of injuries in Kyokoshin was (24.1%), Karate (19.5%) (X=448.46, P=0.000). In all three fields, there were injur...

this editorial refers to some experiences which occurred during translation the novel by alaa al aswaani “yaqubian building “. these experiences include the quality of translating the long sentences and translating the name as sentences, considering the iranian culture in translating and translating the examples and dialogues. the method of confrontation with the feminine and masculine pronounc...