The NMR characteristics of [14-38]Abu, a synthetic variant of BPTI that is partially folded in aqueous buffer near neutral pH, support a model of early folding events which begin with stabilization of the nativelike, slow exchange core [Barbar, E., Hare, M., Daragan, V., Barany, G., and Woodward, C. (1998) Biochemistry 37, 7822-7833 (1)]. In partially folded [14-38]Abu, urea denaturation profil...

To study the structural and functional roles of the cysteine residues at positions 36, 41, and 46 in the transmembrane domain of phospholamban (PLB), we have used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptide synthesis to prepare alpha-amino-n-butyric acid (Abu)-PLB, the analogue in which all three cysteine residues are replaced by Abu. Whereas previous studies have shown that repla...

During asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract for extended periods of time without causing symptoms of urinary tract infection. Previous studies indicate that many Escherichia coli (E. coli) strains that cause ABU have evolved from uropathogenic E. coli (UPEC) by reductive evolution and loss of the ability to express functional virulence factors. For instance, the p...

Murad Abu-Khalaf Suat Gumussoy MIT CSAIL, MIT, Cambridge, MA IEEE Member [email protected] [email protected] February 19, 2018 Abstract We prove that an auxiliary two-point boundary value problem presented in V. L. Kharitonov, Lyapunov matrices for a class of time delay systems, Systems & Control Letters 55 (2006) 610-617 has linearly dependent boundary conditions, and consequently a unique solutio...

The "Queen of Fruits" mangosteen (Garcinia mangostana L.) produces commercially important fruits with desirable taste of flesh and pericarp rich in xanthones with medicinal properties. To date, only limited knowledge is available on the cytogenetics and genome sequences of a common variety of mangosteen (Abu Bakar et al., 2016 [1]). Here, we report the first single-molecule real-time (SMRT) seq...

Take Heart in the Age of ''Omics'' Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000141017.99175.dd 2004;95:335-336 Circ Res. http://circres.ahajournals.org/content/95/4/335 World Wide Web at: Th...

Fung 11, Abu-Elmagd K, Todo S, Shapiro R, Tzakis A, Jordan M, Armitage J, Jain A, Martin M, Bronster 0, Stieber A, Kormos R, Selby R, Gordon R, Starzl TE. FK506 in clinical organ transplantation. John J. Fung, Kareem Abu-Elmagd, Saloro Todo, Ronald Shapiro, Andreas Tzakis, Mark Jordan, John Armitage, Ashok Jain, Maureen Martin, Oscar Bronster, Andrei Stieber, Robert Kormos, Robert Selby, Robert...

Studies show that the pH of the malaria parasite’s digestive vacuole (DV) plays a key role in the physiological functions of this organelle and antimalarial drug accumulation, and yet is technically difficult to measure. In this study, a flow cytometry-based technique was developed to measure the DV pH using a ratiometric pH indicator, FITC-dextran loaded into the DV of saponin-permeabilized pa...

The aim of this purpose was to compare injury mechanism in boys’ amateur epical athletes in Kyokushin, Karate and Aikido. 95 Aikido athletes, 83 Kyokushin ka athletes, 76 Karate ka were randomly selected from Shiraz clubs. Data were analyzed by Χ test. The results showed that the rate of injuries in Kyokoshin was (24.1%), Karate (19.5%) (X=448.46, P=0.000). In all three fields, there were injur...

As a country, the United Arab Emirates has developed very rapidly from a developing country with a largely nomadic population, to a modern and wealthy country with a Western lifestyle. This economic progress has brought undoubted social benefits and opportunities for UAE citizens, including a high and increasing life expectancy. However, rapid modernization and urbanization have contributed to ...