∗Based on my talk at the symposium The Dynamics of Possible Nuclear Extinction held February 28–March 1 2015 at The New York Academy of Medicine: http://totalwebcasting.com/view/ ?id=hcf cided to build a contraption called the Spectacular Thermonuclear Unpredictable Population Incineration Device, abbreviated STUPID. It’s arguably the the most costly device ever built on this beautiful spinning...

We report the results of two investigations requested by the Scienti c Committee regarding alternative methods for Bayesian synthesis assessment of the Bering-Beaufort-Chukchi Seas stock of bowhead whales (Balaena mysticetus). The rst series of studies examines the e ect of assuming that the historic pelagic catch record is known without error. We propose a model for variability in the historic...

We apply a novel methodology to the study of Newfoundland cod fisheries in order determine reasoned and acceptable chronological value series for total catch amounts early modern period where data are scarce. The paper focuses on two main protagonists arena that period: France England. 1675–1790 has been selected as viable representative chronology case data, while available part, limited often...

We analyzed angling catch records for 341,959 muskellunge (Esox masquinongy) from North America to test for a cyclic lunar influence on the catch. Using periodic regression, we showed that the number caught was strongly related to the 29-day lunar cycle, and the effect was consistent across most fisheries. More muskellunge were caught around the full and new moon than at other times. At night, ...

BACKGROUND Rheumatoid arthritis (RA) is characterized by gradual joint destruction. Tocilizumab (TCZ) significantly suppresses symptoms, however not all patients are protected from joint damage. We investigated whether early measurement of specific biomarkers could predict early joint protection response to tocilizumab. METHOD Serum biomarkers (CRPM, VICM, C1M, C2M, C3M (MMP-degraded CRP, vim...

14 We report analyses of a dataset spanning 38 years of near-annual fishing for Antarctic toothfish 15 Dissostichus mawsoni, using a vertical setline through the fast ice of McMurdo Sound, 16 Antarctica, 1972-2010. This constitutes one of the longest biological time series in the Southern 17 Ocean, and certainly the longest for any fish. Fish total length, condition and catch per unit 18 effort...

Circulating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leukocytes and with peripheral node addressin (PNAd) on high endothelial venules. Mechanical forces can strengthen (catch) or weaken (slip) bonds between biological molecules. How these mechanochemical pr...