نتایج جستجو برای: accumulated damage
تعداد نتایج: 262190 فیلتر نتایج به سال:
This paper is concerned with opportunistic maintenance on a multi-component cumulative damage shock model with stochastically dependent components. A component fails when its cumulative damage exceeds a given threshold, and any such a failure creates a maintenance opportunity, and triggers a simultaneous repair on all the components, including the non-failed ones, such that damages accumulated ...
Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9h post-infection, with no effect of infection on I...
Highly pathogenic avian influenza (HPAI) virus can spread rapidly, resulting in high mortality and severe economic damage. To minimize the damage incurred from such diseases, it is necessary to develop technology for analysing livestock disease and predicting livestock disease propagation. In this study, we propose a novel big data analytics model using extensive volumes of livestock disease oc...
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any ...
Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron tr...
Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societies with their aging populations. Accumulation of DNA damage has been proposed to contribute to these impairments, but direct proof that DNA damage results in impaired neuronal plasticity and memory is lacking. Here we take advantage of Ercc1(Δ/-) mutant mice, which are impaired in DNA nucleotide ...
Barium osumilite (BMAS) ceramic matrix composites reinforced with SiC-Tyranno fibers are tested in a cyclic loading protocol. Broadband acoustic emission (AE) sensors are used for monitoring the occurrence of different possible damage mechanisms. Improved use of AE indices is proposed by excluding low-severity signals based on waveform parameters, rather than only threshold criteria. The applic...
Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us to investigate the importance of clustered DNA damage in the biological effect...
the impacts of dust and sand storms (dss) on people, crops, livestock, infrastructure and health are well documented. data have accumulated on the deleterious effects of dust aerosols when they settle on plants. sand blasting of low growing plants is a common cause of failure in reforestation efforts. burial of plants by moving sands are also a cause of much damage. the physics of moving sand a...
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