The major objective of the current study is to implement a plan enhance dissolution rate and oral bioavailability poorly water-soluble aceclofenac. drug classified according biopharmaceutical classification system as class II drug. Amorphous alkalinized aceclofenac solid dispersion was formulated ternary mixture. This mixture prepared by introducing polymeric carriers [polyvinylpyrrolidone, Hyd...

The current research work involves preparation of fast dissolving tablets of Aceclofenac by direct compression method using different concentrations of Lepidium sativum mucilage as natural superdisintegrant. A two-factor three-level (3(2)) factorial design is being used to optimize the formulation. Nine formulation batches (D1-D9) were prepared accordingly. Two factors as independent variables ...

The objective of this study was to prepare and evaluate calcium alginate (CA) microbeads with calcium chloride as cross-linking agent for aceclofenac sodium by ionotropic external gelation method. Calcium alginate microbeads represent a useful tool for oral sustained/ controlled drug delivery but show several problems, mainly related to the stability, and rapid drug release at higher pH that, i...