background bipolar disorder is a biological brain disorder which is associated with debilitating fluctuation in mood and adverse effects on patients, their families and society. the importance of genetics and its role in bipolar disorder is a controversial issue to discuss. evidence indicates a relation between the risk of bipolar disorder and specific genes. amongst the genes whose role has be...

There is a large-amplitude circadian rhythm of indoleamine metabolism in the retina-pigment epithelium of the chicken. N-Acetyltransferase activity (arylamine acetyltransferase; acetyl-CoA:arylamine N-acetyltransferase, EC 2.3.1.5) and melatonin content are 15-fold higher at night than during the day in a cycle of a 4-fold increase during the subjective night. Light at midnight inactivates N-ac...

New sublines of Chinese hamster CHL cells stably expressing human NATI or NAT2 A'-acetyltransferases or 0-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human NAT2 A'-acetyltransferase exhibited the highest sensitivity to the ciastogen...

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Platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) induced in isolated rat peritoneal and human peripheral neutrophils a rapid and potent activation of the PAF biosynthetic enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase (EC 2.3.1.67). The PAF-induced activation of the neutrophil acetyltransferase (8-10 times basal neutrophil activity) was ...

ROSKOSKI, ROBERT, JR., RUTH I. MCDONALD, LAURA M. ROSKOSKI, WILLIAM J. MARVIN, AND KENT HERMSMEYER. Choline acetyltransferase activity in heart: evidence for neuronal and not myocardial origin. Am. J. Physiol. 233(6): H642-H646, 1977 or Am. J. Physiol.: Heart Circ. Physiol. 2(6): H642-H646, 1977. -Choline acetyltransferase (EC 2.3.1.6) catalyzes the following reaction: acetyl coenzyme A + choli...

OBJECTIVE To study the effects of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549. METHODS N-acetyltransferase antibodies were prepared. The human lung cancer A549 cells were cultivated randomly in the wells of culture plate, and divided into the control group, and berberine 0.0008, 0.008, 0.08, 0.8 and 1.6 mM treatment groups, with 3 wells...