نتایج جستجو برای: acid amide hydrolase
تعداد نتایج: 772887 فیلتر نتایج به سال:
Treatment of carboxypeptidase Y with ~4C-iodoacetamide caused a drastic reduction in the peptidase activity towards FA-Phe-$Leu-OH while the esterase activity towards FA-Phe 89 the amidase activity towards FA-PhelNH2 and the peptidyl amino acid amide hydrolase activity towards FA-Phe-$GIy-NH2 were much less affected. The loss of peptidase activity could be correlated with the incorporation of a...
The melting curves of fatty acid amide hydrolase (FAAH) in the presence of 29 reversible inhibitors were measured using a thiol-reactive fluorophore. The thermal stability (T(m)) of the FAAH/inhibitor complex varied significantly depending on the chemical characteristics of the inhibitors, notably variations in the head group. Two separate distributions were observed when T(m) was plotted again...
BACKGROUND The endocannabinoid system includes G-protein-coupled cannabinoid receptors, the endocannabinoids N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and multiple enzymes involved in the biosynthesis and degradation of endocannabinoids, including the anandamide metabolizing enzyme fatty acid amide hydrolase. Endocannabinoids play an important role in the physiologic c...
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