Retrovirus-mediated sFlt-1 gene modification was performed to examine the influence of VEGF in controlling the growth of an experimental osteosarcoma in mice. Human osteosarcoma G-292 cells were in vitro infected with retroviral vectors encoding soluble Flt-1 or LacZ gene before transplanted into proximal tibiae of immune deficient SCID mice to establish experimental orthotopic osteosarcoma. Da...

Transposon Tn5-Mob mutagenesis allowed the selection of a Sinorhizobium fredii HH103 mutant derivative (SVQ 292) that requires the presence of uracil to grow in minimal media. The mutated gene, pyrF, codes for an orotidine-5 - monophosphate decarboxylase (EC 4.1.1.23). Mutant SVQ 292 and its parental prototrophic mutant HH103 showed similar Nod-factor and lipopolysaccharide profiles. The symbio...

AMA Tyrovolas K, Lampropoulos K. A nightmarish case of simultaneous coronary perforations in the catheterization laboratory. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(3):292-293. doi:10.5114/aic.2023.131485. APA Tyrovolas, K., & Lampropoulos, (2023). Interwencyjnej, 19(3), 292-293. https://doi.org/10.5114/aic.2023.131485 Chicago Konstantinos, and Konstanti...

Tartaric acid modified wheat bran was utilized as adsorbent to remove methyl blue, a basic dye from aqueous solution. Batch experiments were carried out to study the effect of various experimental parameters such as initial solution pH, contact time, initial dye concentration and adsorbent dosage, on dye adsorption. The results showed that the modification of wheat bran by tartaric acid signifi...

Parathyroid glands from laying hens were also  xed in percent glutaraldehyde in phosphate buffer (0.1 M, 7.3 pH) for araldite embedding and used for electron microscopy. For routine histological observations, sections of 5 to 6 um thickness were cut and stained by, Mayer’s haemalum and eosin-phloxine, Masson’s trichrome, Crossman’s modi cation of Mallory’s triple stain, van Gieson’s method fo...

CC-292, a potent Bruton tyrosine kinase inhibitor, is under development for the treatment of B-cell malignancies. An analysis was performed to develop a population pharmacokinetic model of CC-292 and assess the influence of demographics and disease-related covariates on CC-292 exposure and to assess the exposure-response (overall response rate) relationship in patients with chronic lymphocytic ...