Vanilmandelic, homogentisic and homovanillic acid excretions were studied in parkinsonian patients on and off L-dopa. Vanilmandelic acid excretions were quantitated both by gas-chromatographic and calorimetric methods. A marked increase in the excretion of this acid was demonstrated in the parkinsonian patient as compared to controls. Although vanilmandelic excretion rises under the influence o...

Filamentous fungi are important cell factories. In contrast, we do not understand well even basic physiological behavior in these organisms. This includes the widespread phenomenon of organic acid excretion. One strong hurdle to fully exploit the metabolic capacity of these organisms is the enormous, highly environment sensitive phenotypic plasticity. In this work we explored organic acid excre...

The elevation of pCO2 which occurs during respiratory acidosis is accompanied by a rise in the concentration of bicarbonate and a fall in the concentration of chloride in serum (1). The increased bicarbonate concentration results from both cellular and renal responses. The cellular response is characterized by the exchange of extracellular hydrogen ions for intracellular cations, thereby contri...

Dietary protein restriction has multiple benefits in kidney disease. Because protein intake is a major determinant of endogenous acid production, it is important that net acid excretion change in parallel during protein restriction. Ammonia is the primary component of net acid excretion, and inappropriate ammonia excretion can lead to negative nitrogen balance. Accordingly, we examined ammonia ...

I. The influence of the gut microflora on protein utilization has been investigated with a series of goodand poor-quality protein diets in germ-free (GF) and conventional (CV) chicks by the measurement of net protein utilization (NPU) and uric acid excretion. 2. The diets used were: 280 g protein per kg dict containing unheated or hcat-damaged albumen (roo gjkg), casein (80 g/kg) and gelatin (1...