INTRODUCTION F OLLOWING Haden’s1#{176}demonstration of the close correlation between spherocytosis and the fragility of erythrocytes to hypotonic saline, Dameshek and Miller5 postulated that spherocytosis was a preliminary stage in the destruction of the red cell; i.e. partial hemolysis. They were able to show experimentally that the degree of spherocytosis was related to the concentration of h...

INTRODUCTION F OLLOWING Haden’s1#{176}demonstration of the close correlation between spherocytosis and the fragility of erythrocytes to hypotonic saline, Dameshek and Miller5 postulated that spherocytosis was a preliminary stage in the destruction of the red cell; i.e. partial hemolysis. They were able to show experimentally that the degree of spherocytosis was related to the concentration of h...

We have investigated the hemolytic mechanisms in a patient with acquired immune hemolytic anemia whose red cells appeared to be coated with IgA alone. The clinical course was similar to that of patients with hemolytic anemia mediated by warm-reacting IgG antibody. Splenic sequestration of red cells was demonstrated, and marked reduction of hemolysis occurred after corticosteroid therapy. Antibo...

Serum transferrin receptors were measured by a sandwich radioimmunoassay procedure in patients with iron deficiency anemia, autoimmune hemolytic anemia and aplastic anemia. The mean circulating transferrin receptor concentration of normal subjects and patients with iron deficiency anemia, autoimmune hemolytic anemia and aplastic anemia are 253 +/- 82 ng/mL, 730 +/- 391 ng/mL, 1,426 +/- 1,079 ng...

Abstract Background: Hereditary red cell enzyme disorders are a group of Non-immune/Spherocytic Hemolytic Anemia, although these disorders are rare and they have not public health problems, the detection of these defects could help to physician in treatment and differential diagnosis. This study evaluated 5 enzymopathies in patients with Hereditary Non –immune/Spherocytic Hemolyti...

W E HAVE OBSERVED three patients' who had developed severe hemolytic anemia following aortic valve replacement with a Starr-Edwards ball valve.2 3 The anemia has persisted from 3 to 6 months following operation. Hemolytic anemia following repair of ostium primum defect with a Teflon patch with a regurgitant jet through the mitral cleft has been described.4-7 Hemolytic anemia following insertion...

Autoimmune hemolytic anemia (AIHA) is an unusual complication of malignancy. We diagnosed primary splenic anaplastic large cell lymphoma (ALCL) in a patient. A seven-year-old boy presented with Coombs test-positive hemolytic anemia. After a course of prednisolone therapy, a complete response for anemia was achieved. Twenty months later, in addition to severe hemolytic anemia, the patient was di...