A three-month-old boy presented congenital hypopituitarism in which the hypothyroid state masked ACTH deficiency. Multiple anterior pituitary hormone deficiencies, including ACTH, were finally confirmed. High basal serum cortisol levels (up to 45.1,ug/dl) were observed during a stressful episode before L-thyroxine replacement therapy was started. Decreased morning serum cortisol levels (5.0 μg/...

OBJECTIVE Some patients with hyperandrogenemia had no identifiable cause, which was named as idiopathic hyperandrogenemia (IHA). The role of the adrenal glands in these patients was investigated. DESIGN Clinical study in patients with IHA at the Endocrinology Department of a University Hospital. PATIENT(S) In this study, 26 pre-menopausal women with IHA and 20 healthy women were included. B...

The function of the hypophyseo-adrenocortical system was investigated by the method described by Robinson, Mattingly, and Cope (1962), based on the principle that if the system is functionally normal the blood cortisol level, which is decreased in the course of corticosteroid therapy, returns to normal after steroid withdrawal. In a number of asthmatic children on steroid therapy the blood cort...

INTRODUCTION This study was aimed at characterizing basal and adrenocorticotropic hormone (ACTH)-induced steroidogenesis in sepsis and nonsepsis patients with a suspicion of critical illness-related corticosteroid insufficiency (CIRCI), taking the use of etomidate-inhibiting 11β-hydroxylase into account. METHOD This was a prospective study in a mixed surgical/medical intensive care unit (ICU)...

Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a paternal history of alcoholism (PHA) and 16 family history negative (FHN) control...

The effects of HS on the welfare poultry have been reported to a transgenerational effect phenotype plasticity. goal our experiment was determine whether parental exposure would impair performance, HPA axis response, or behavior their offspring. We treated adult drakes and hens (n = 80 ducks/treatment) at peak lay with control temperature for 3 weeks incubated eggs collected from last days expe...

The efficiency of various laboratory and radiological investigations in the differentiation of ectopic from pituitary dependent Cushing's syndrome was studied, based on findings in 23 patients with verified Cushing's disease and seven patients with the ectopic ACTH syndrome. Clinical features strongly favouring the ectopic type were male sex and history for less than 18 months. Basal biochemica...

The use of carbamazepine has been reported to be an effective treatment for severe depression. We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test (FST) are blocked by chronic treatment with adrenocorticotropic hormone (ACTH). In the present study, we examined the effect of the chronic administration of carbamazepine on the FST and...