IL-31 receptor blockade suppresses pruritus of atopic dermatitis. However, cell type-specific contributions to itch, its expression mechanism, and the downstream signaling pathway induce itch remain unknown. Here, using conditional knockout mice, we demonstrated that IL-31-induced required sensory neuronal STAT3. was decreased in STAT3 deficient indicating dependent on neurons. In addition, an ...

Aldosterone is one of the most essential hormones synthesized by adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) a newly discovered aldosterone receptor, which proposed to mediate non-genomic pathways while hormone simultaneously interacts with mineralocorticoid receptor. In contrast its cardio-protective role in postmenopausal women ...

The structure of purified preparations of activated (DNA-binding) glucocorticoid receptor (GR) was analyzed in the presence or absence of DNA. A 35-base pair DNA fragment harboring a strong GR-binding site from the mouse mammary tumor virus promoter (-189/-166) was used for stoichiometric analysis of the GR . DNA complex. Glycerol gradient centrifugation was utilized in order to separate the 6 ...