Genome-editing systems such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology have uncovered new opportunities to model diseases chronic lymphocytic leukemia. CRISPR/Cas9 is an important means of advancing functional studies Chronic Lymphocytic Leukemia (CLL) through the incorporation, elimination and modification somatic mutations in CLL models.

Cytidine triphosphate synthetase (CTP synthetase) activity was measured in extracts from normal and malignant lymphoid cells. A range of enzyme activities was found in the majority of the lymphoproliferative disorders examined, with acute lymphocytic leukemia, nodular poorly differentiated lymphocytic lymphoma, and diffuse histiocytic (large cell) lymphoma (DHL) types exhibiting the widest rang...

Nonhuman primate antisera defining leukemia-associ ated and normal Tand B-lymphocyte-associated anti gens were used to characterize serologically the cells from acute myelomonocytic leukemia (AMML) and chronic myelogenous leukemia patients in blast crisis (CML-BC). Earlier studies demonstrated that nonhuman primate an tisera to chronic lymphocytic leukemia, acute myelogen ous leukemia, and chro...

INTRODUCTION Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow. AIM Identify most frequent oral manifestations in children with acute lymphocytic leukemia under chemotherapy treatment. METHODOLOGY The research was conducted on the electronic database PubMed/Medline, Science Direct...

The most common hematological malignant diseases of the childhood are acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Minimal residual disease is gaining importance nowadays both for therapy efficacy follow up and relapse risk estimation. Owing to fast technological developments, minimal residual disease (MRD) can be evaluated both by molecular and flow cytometric methods, pr...

Abbreviations: acute lymphoblastic leukemias, (ALLs); acute myeloid leukemia, (AML); arsenic trioxide, (ATO); B-cell chronic lymphocytic leukemia, (B-CLL); blast crisis, (BC); chronic lymphocytic leukemias, (CLL); CML-Acceleration Phase/Blast Crisis, (CML/AP/BC); CML-Bone Marrow Transplantation patients, (CML-BMT); CML-Chronic Phase patients, (CML/CP); DNA binding domain, (DBD); dominant-negati...

Background The survival for pediatric leukemia patients is approaching 90%, but there are patient subgroups that fare poorly including those with relapsed, or high-risk, acute lymphocytic and acute myeloid leukemia (ALL and AML, respectively). For these reasons, there is an unprecedented need for more effective therapies. Adoptive cellular therapy (ACT) has been shown to be an effective anti-tu...

Microsatellites are important highly polymorphic genetic markers dispersed in the human genome. Using a panel of 22 (CA)n repeat microsatellite markers mapped to recurrent breakpoint cluster regions specifically involved in leukemia, we investigated 114 adult leukemias (25 acute lymphocytic leukemia [ALL], 32 acute myeloid leukemia [AML], 36 chronic lymphocytic leukemia [CLL], and 21 chronic my...

Arsenic trioxide inhibits growth and promotes apoptosis in many different cancer cell lines. The National Cancer Institute is working cooperatively with research centers across the U.S. to evaluate its clinical activity in hematologic malignancies, such as acute promyelocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, non-Hodgkin's lymphoma, Hodg...