Ischemia remains the major cause of acute renal failure (ARF) in the adult population [1]. Clinically a reduction in glomerular filtration rate (GFR) secondary to reduced renal blood flow can reflect prerenal azotemia or acute tubular necrosis (ATN). More appropriate terms for ATN are acute tubular dysfunction or acute tubular injury, as necrosis only rarely is seen in renal biopsies, and renal...

Autoimmune hemolytic anemia (AIHA) is a rare disease with rate of 1-3 in 100,000 adults. AIHA are defined as primary (idiopathic) or secondary depending on the presence absence accompanying disease. Secondary causes include drugs, immunodeficiencies, infections, other autoimmune diseases, malignancies. Here, we report an 42-year-old female presented to us diarrhea, nausea-vomiting, fever, chill...

Abstract Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in specific section nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement necroptosis well characterized, genetic evidence supporting contribution ferroptosis lacking. Here, we demonstrate that loss suppressor protein 1 ( Fsp1 ) or targeted manipulation ...

PURPOSE The aim of this study is to describe the occurrence of necrotic tubular cells in kidneys of non-macerated fetuses. METHODS Description of histology and immunostaining results using C9 immunostain of proximal tubular epithelium of kidneys from 30 consecutive non-macerated fetuses' autopsies. RESULTS the gestational age ranged from 13 to 22 weeks. The mean gestational age was 18.6 wee...

Acute tubular necrosis causes a loss of renal function, which clinically presents as acute kidney failure (AKI). The biochemical signaling pathways that trigger necrosis have been investigated in detail over the past 5 years. It is now clear that necrosis (regulated necrosis, RN) represents a genetically driven process that contributes to the pathophysiology of AKI. RN pathways such as necropto...

objective(s): the aim of this study was to evaluate the effect of subacute administration of propylthiouracil (ptu) on gentamicin (gm)-induced nephrotoxicity in male rats.   materials and methods: male wistar rats were divided into 4 experimental groups as follow: (1) control group: isotonic saline (1 ml/kg, ip. for 18 d), (2) gm group: 100 mg/kg, ip for 8 d, (3) ptu group: ptu (10 mg/kg, ip fo...

A young renal transplant recipient received living kidney from his father; the Centers for Disease Control and Prevention (CDC) cross match was all negative. He had oliguria 5 hours after with fever neutrophil leukocytosis. Doppler ultrasonogram revealed increased cortical echo Resistive Index suggesting acute rejection or tubular necrosis. Renal biopsy T cell mediated (acute TCMR) Grade IIA. T...

The paradigm for recovery of the renal tubule from acute tubular necrosis is that surviving cells from the areas bordering the injury must migrate into the regions of tubular denudation and proliferate to re-establish the normal tubular epithelium. However, therapies aimed at stimulating these events have failed to alter the course of acute renal failure in human trials. In the present study, w...

The specificity of gentamicin for vitamin E deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. To determine the ways in which vitamin E manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...