Recent evidence indicates an important role of inflammation pathways, airways remodeling and epithelium activation in asthma genetics. In particular, transcriptome studies have detected differentially expressed genes involved in eosinophil apoptosis, the arginase pathway, response to allergens or interleukins, and to inhaled corticosteroids. Candidate gene and genome wide studies have localized...

Asthma Genetic Association studies have been plagued by methodologic problems that are common in all studies of complex traits: small sample size, lack of replication, and lack of control of population stratification. Despite this, the field has identified 43 replicated genes from association studies. The most frequently replicated are: TNF alpha, IL4, FCERB, Adam 33, and GSTP1. Several genes h...

Asthma is a complex heterogeneous disease, the development of which determined by interaction many predisposition genes and environmental factors. Many epidemiological studies have shown that single nucleotide polymorphism (SNP) in FCER1B (rs1441586), FCER2 (28364072), ADAM33 (rs528557) are associated with risk asthma. However, results inconsistent inconclusive. The aim this study was to determ...