Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible...

The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2 variants from influenza A and B that contains only the pore-binding site is sensitive to amantadine inhibition, suggesting that the primary site of inhibi...

some of the adamantane properties were calculated in this study. chemical shift, free energy ofsolvation, free energy of cavity formation, henry's law constant, and other properties ofadamantane in dry phase, three solvents and three temperatures have been calculated with abinitio method base on density functional theory (dft) at b3lyp/6-31g, b31yp/6-31g*, b3lyp/6-31+g* and b3lyp/6-31++g** leve...

In the crystal structure of the title compound, C(14)H(23)NOSi, cyclic dimeric units are established by two very weak hydrogen bonds of the type C-H⋯N with an H⋯N distance which is only slightly shorter than the sum of the van der Waals radii of 2.75 Å. The graph-set descriptor on the unitary level is R(2) (2)(14) for the cyclic dimer.

Two guanosine analogues have been designed and synthesized by connecting one (1) or three adamantane branches (2). The compound containing a single adamantane branch formed G-quartets in acetonitrile solution, and was then transformed into a G-ribbon gel at concentrations higher than the critical gelation concentration. In contrast, the compound with three adamantane branches precipitated after...

Solid state and solution evidence confirms the embedding of an adamantane-like, Ru4O6 fragment by the divacant, gamma-decatungstosilicate ligand. The resulting complex catalyzes water oxidation to oxygen with TON up to 500 and TOF > 450 h-1.

The synthesis of deep cavitands with functionalized acetals as a fourth-wall is described. Recognition properties and stabilities of the complexes of two representative cavitands with aliphatic, aromatic, carbocyclic and adamantane guests were evaluated by NMR methods.

Gelation kinetics of hydrogels is closely linked to many applications such as the development of injectable and printable hydrogels. However, the control of gelation kinetics without compromising the structure and other properties of the hydrogels, remains a challenge. Here, we demonstrate a method to control the gelation kinetics of cucurbit[7]uril-adamantane (CB[7]-AD) cross-linked supramolec...

In the title compound, C(17)H(21)N, the dihedral angle between the benzene ring and the imine group (-N=) is 5.1 (4)°. In the adamantane group, the C-C-C bond angles range from 107.88 (19) to 111.33 (17)°. Only weak van der Waals inter-actions contribute to the contribute to the packing of the molecules in the crystal..