BACKGROUND AND PURPOSE Apparent diffusion coefficient (ADC) thresholds for tissue infarction have been identified in acute stroke. IV tissue plasminogen activator (tPA) is associated with tissue salvage. We hypothesized that tPA would lower the ADC threshold for infarction. METHODS ADC and mean transit time (MTT) maps were generated for 26 patients imaged within 6 hours of stroke onset (12 tP...

Introduction: Diffusion-weighted Imaging (DWI) and the derived apparent diffusion coefficient (ADC) were reported by several groups [1,2] to differentiate cancerous and healthy tissue in the prostate. The Intravoxel Incoherent Motion (IVIM) Theory, which predicts an additional component in the signal equation due to perfusion [3], could recently be applied to the liver and the pancreas [4,5]. F...

conclusion our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding dwi, mr imaging to routine soft tissue tumor protocols may improve diagnostic accuracy. results there was only one patient with a malignant cystic tumor and was not included in the statistical analysis. the median adc values of benign and malignant tumors were 2.31 ± 1.2...

PURPOSE Differentiating significant cancer from insignificant cancer is a major challenge in active surveillance (AS) for prostate cancer. We evaluated whether the apparent diffusion coefficient (ADC) grade from 3-T diffusion-weighted magnetic resonance imaging (DW-MRI) is useful to exclude men with unfavorable pathological features from men meeting current AS eligibility criteria. METHODS Am...

background and purpose : there has been no report in which preoperative evaluation of adc for prediction of post therapeutic outcome was presented. the aim of our study was to retrospectively evaluation the use of the apparent diffusion coefficient (adc) for the prediction of malignancy and the outcome of malignant astrocytic tumors. methods: we reviewed mri of 26 male and 14 female patients wi...

Introduction: Transverse relaxation rates, R2 and R2* and the apparent diffusion coefficient (ADC) are all typically estimated from the exponential decay of MR signal magnitude as a function of either echo time (for R2 and R2*) or b-value (for ADC). Changes in R2 and R2* induced by ultrasmall paramagnetic iron oxide (USPIO) contrast agents, along with ADC, have recently been utilised to estimat...

Based on the assumption that apparent diffusion coefficients (ADCs) define high-risk clinical target volume (aCTVHR) in high-grade glioma in a cellularity-dependent manner, the dosimetric effects of aCTVHR-targeted dose optimization were evaluated in two intensity-modulated radiation therapy (IMRT) plans. Diffusion-weighted magnetic resonance (MR) images and ADC maps were analyzed qualitatively...

OBJECTIVE To describe the apparent diffusion coefficient (ADC) in a series of severe traumatic brain injuries, their clinical and outcome features, and possible implications. DESIGN A descriptive, observational case-series study was carried out. PATIENTS AND INTERVENTIONS Patients with severe traumatic brain injuries (TBIs) admitted to the ICU were subjected to MRI study using a 1.5 T scann...