The predominance of high molecular weight PRL, or macroprolactinemia, has long been known in hyperprolactinemic patients with maintained fertility. Among 1,106 consecutive patients investigated for hyperprolactinemia in our center over a 10-yr period, serum PRL chromatography was performed in 368 cases because of discordant clinical, biological, or neuroradiological findings. We prospectively s...

discussion benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity. although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasized to distinct sites. it remains to be determined whether this benign metastasizing pleomorphic adenoma is really low grade salivary malignancy. ...

BACKGROUND The aim of this study was to detect the expression of cold-inducible RNA-binding protein in pituitary adenoma and to determine its effects on tumor recurrence. MATERIAL/METHODS We collected a total of 60 post-op samples collected from pituitary adenoma patients (including 20 cases of invasive pituitary adenoma, 20 cases of non-invasive adenoma, and 20 cases of non-invasive recurren...

Abstract Cushing’s Disease is a well known entity but the difficulty of diagnosis often underappreciated. Given wide spectrum clinical presentation and pitfalls with each diagnostic evaluation, (CD) difficult in practice, even pathological analysis. A 37 year old female history presented for her third transphenoidal resection to our institution. She was diagnosed pituitary microadenoma 16 years...

Introduction: Diagnosis and localization of offending glands in hyperparathyroid patients is a subject that has always concerned surgeons. Until two decades ago this could only be achieved through complete neck exploration by the surgeon. In recent decades, with introduction of better imaging techniques such as advanced sonography and isotopic scans, remarkable progress has been made in this ...

BACKGROUND Prior studies suggest that histamines may modulate the development of colorectal neoplasia. AIM To assess whether histamine receptor antagonist use was associated with adenoma formation. METHODS Patients (n = 2366) were drawn from three adenoma chemoprevention trials. All underwent baseline colonoscopy with removal of adenoma(s) and were deemed free of remaining lesions; they wer...

ectopic paratliyroid adenoma might create a clinical dilemma in patients with hypercalcemia. radioisotopic scan is a sensitive and noninvasive method which can be useful in these patients. in this report a case of ectopic parathyroid adenoma is presented and the usefulness of tc-99m-mibi scintigraphy as compared with other modalities is discussed.