Introduction : Sarcopenia is defined as a loss of muscle mass and strength. ATP homeostasis crucial during myogenesis. We determined how the purinergic system modulates myogenesis using dipyridamole (blocks adenosine taken up by cells) tenofovir (inhibits release) in myoblast cell line. Methods: C2C12 cells were differentiated presence/absence tenofovir/dipyridamole, with/without A2B selective ...

background and aim: caffeine at low doses blocks adenosine receptors. these receptors are present in all parts of the body including auditory and vestibular system. this study aimed to evaluate the effects of caffeine on cervical vestibular evoked myogenic potential (cvemp). methods: in this interventional double-blind study, 40 cases (20 females and 20 males) aged 18-25 years were randomly ass...

Objective: Cinnamaldehyde may be responsible for some health benefits of cinnamon such as its neuroprotective effects. We aimed to investigate the cinnamaldehyde neuroprotective effects against amyloid beta (Aβ) in neuronal SHSY5Y cells and evaluate the contribution of N-methyl-D-aspartate (NMDA), ryanodine, and adenosine receptors and glycogen ...

Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

-The objective of this investigation was to determine whether the regulation of extracellular adenosine levels by smooth muscle cells (SMCs) from conduit arteries (aorta) and resistance microvessels (renal arterioles) is different in spontaneously hypertensive rats (SHR) versus normotensive Wistar-Kyoto (WKY) rats. Basal extracellular adenosine levels were decreased in cultured aortic and arter...

Many foods have been reported to be effective against thrombosis, but most of them may difficult ingest in doses prevent the disease. In this study, we focused on strawberries as one antithrombotic activities because they are highly palatable many people and several intake methods (e.g., raw fruits, juices, jams, etc.). strawberry ‘Minomusume’ was selected a material explore antiplatelet active...

Introduction and Aim:The atherosclerosis is the major cause of morbidity mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose lipid metabolism through adenosine. This study aimed to correlate index with adenosine levels Type 2 patients. The aim find association between serum ADA index....

Intracellular adenosine formation and release to extracellular space was studied in WI-L2-B and SupT1-T lymphoblasts under conditions which induce or do not induce ATP catabolism. Under induced conditions, B lymphoblasts but not T lymphoblasts, release significant amounts of adenosine, which are markedly elevated by adenosine deaminase inhibitors. In T lymphoblasts, under induced conditions, on...