INTRODUCTION The study aimed to evaluate the relationship between plasma asymmetric dimethylarginine (ADMA) concentration and development of left ventricular diastolic dysfunction (LVDD) in patients with essential hypertension (EH). Moreover, an attempt was made to define independent risk factors of LVDD in patients with EH. MATERIAL AND METHODS A group of 106 individuals with EH was obtained...

Nitric oxide (NO) has been suggested to play a key role in the pathogenesis of pulmonary hypertension (PH). To determine which mechanism exists to affect NO production, we examined the concentration of endogenous nitric oxide synthase (NOS) inhibitors and their catabolizing enzyme dimethylarginine dimethylaminohydrolase (DDAH) activity and protein expression (DDAH1 and DDAH2) in pulmonary arter...

Hypoadiponectinemia and Endogenous Nitric Oxide Synthase Inhibitor in Hypertension To the Editor: We read with great interest the article by Xing et al1 dealing with the relationship between adiponectin and vascular insulin resistance in hypertension. The results of their study demonstrated that hypoadiponectinemia induced vascular insulin resistance in young spontaneously hypertensive rats. In...

ADMA, a product of protein degradation, is an endogenous nitric oxide synthase inhibitor that has been shown to be increased in mouse models of allergic airway inflammation and to be associated with airways hyperresponsiveness in these animals [2]. ADMA has also been reported to be increased in sputum samples [2] and exhaled breath condensates [3] from paediatric patients with asthma. Increased...

The aim of the present study was to investigate the effects of a 12 week detraining after a 16 week multicomponent training program including strength, anaerobic and aerobic exercises on the main determinants of Asymmetric Dimethylarginine (ADMA), homocysteine (Hcy) and some physiological markers. For this purpose, twenty-three well-trained young wrestlers (14.9±1.1 yr, 46.6 ± 9.949.4 ± 9.6kg, ...

Arginine methylation is a common posttranslational modification that has far-reaching cellular effects. Trypanosoma brucei is an early-branching eukaryote with four characterized protein arginine methyltransferases (PRMTs), one additional putative PRMT, and over 800 arginine methylated proteins, suggesting that arginine methylation has widespread impacts in this organism. While much is known ab...

BACKGROUND Patients with preeclampsia have higher circulating asymmetric dimethylarginine (ADMA). However, whether circulating ADMA is elevated before the diagnosis of preeclampsia has not been determined. METHODS A meta-analysis of observational studies that reported circulating ADMA level before the onset of preeclampsia was performed. Pubmed and Embase were searched. Standardized mean diff...