نتایج جستجو برای: adrenoceptor antagonists
تعداد نتایج: 56535 فیلتر نتایج به سال:
It has been suggested that there is a link between epinephrine synthesis and the development of β2-adrenoceptor-mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize β-adrenoceptor-mediated relaxation and facilitation of norepinephrine release in the aorta of phenylethanolamine-N-methyltransferase-knocko...
It has been suggested that there is a link between epinephrine synthesis and the development of b2-adrenoceptor–mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize b-adrenoceptor–mediated relaxation and facilitation of norepinephrine release in the aorta of phenylethanolamine-Nmethyltransferase–knockou...
The pharmacological characteristics of the postjunctional alpha-adrenoceptors of vascular smooth muscle were studied in ring segments of thoracic aorta, superior mesenteric, and central ear arteries of 4- and 8-week-old, and young adult (12- to 16-week-old) rabbits. Norepinephrine (alpha 1, alpha 2-agonist), phenylephrine (alpha 1-agonist), and UK 14,304-18 (alpha 1-agonist) caused a concentrat...
On the basis of data obtained in rabbits, the imidazoline receptor ligand rilmenidine has been suggested to decrease blood pressure in humans by activating central a2A-adrenoceptors. A prerequisite for this hypothesis was the unproved assumption that rabbit and human a2A-adrenoceptors are equally activated by rilmenidine. Because a2A-adrenoceptors in the brain and on cardiovascular sympathetic ...
For the pharmacological treatment of frequency, urgency and/or urge incontinence due to bladder overactivity, anticholinergics have been used as first-choice drugs. However, these drugs can exert severe side effects (accommodation paralysis, constipation, tachycardia, dry mouth and blurred vision) and some patients are refractory to their actions. Thus there is a need for new drug therapies wit...
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