Results Among 1534 preschool children, 1219 (90.0%) has completed response to questionare. Complete data were available for 1169 children about past medical history including wheeze, familial history and skin prick test. The prevalence of wheeze was 29.4%.It was found that incidence of wheezing declined and incidence of aeroallergen sensitization increased with age. Two hundred and ten preschoo...

As the incidence of allergic diseases, including atopic dermatitis (AD), increases, there is continuing interest about the underlying cause of these conditions. There is little question that the causes of AD are multifactorial and include allergy, genetics, infection, and climactic and emotional influences. The degree to which each of these components has a role in the causation of AD is contro...

Methods A prospective 10-year-follow-up study has been designed to evaluate 194 LAR patients and 97 healthy controls. All LAR patients had positive response to nasal allergen provocation test (NAPT) with at least one aeroallergen. Demographic and clinical questionnaire, spirometry, skin prick testing, and serum specific IgE antibodies to common aeroallergens were evaluated yearly, and NAPT were...

IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test this hypothesis, we compared the responses induced by the aeroallergen ovalbum...

The aim of this study was to determine the aeroallergen sensitivity of allergic rhinitis patients. A total of 100 cases (female: 59, male: 41, aged between 10-59 years, mean age 27.9 years) who were diagnosed with allergic rhinitis by history and clinical presentation, underwent a prick skin test with 30 aeroallergens, and the important sensitizing allergens were assessed. Skin test reactivity ...

BACKGROUND Asthma and allergic rhinitis affect 15% and 38% of South African (SA) children, respectively. The housedust mite (HDM) is the most significant indoor aeroallergen. Typical HDM species include Dermatophagoides pteronyssinus, D. farinae and Blomia tropicalis. Conventional skin-prick testing (SPT) panels only test for Dermatophagoides. B. tropicalis has been described in the tropical an...