Fever appears to protect ectotherms against infectious disease perhaps because it increases their aerobic metabolic capacity, which is temperature-dependent. Mammals, however, have a high aerobic capacity and normally regulate a high body temperature. Thus, the further increase in temperature induced by interleukin-1 may be dangerous, and the resulting increase in aerobic capacity may not be ne...

One of the most important events in vertebrate evolution was the acquisition of endothermy, the ability to use metabolic heat production to elevate body temperature above environmental temperature. Several verbal models have been proposed to explain the selective factors leading to the evolution of endothermy. Of these, the aerobic capacity model has received the most attention in recent years....

Regular exercise training is recognized as a powerful tool to improve work capacity, endothelial function and the cardiovascular risk profile in obesity, but it is unknown which of high-intensity aerobic exercise, moderate-intensity aerobic exercise or strength training is the optimal mode of exercise. In the present study, a total of 40 subjects were randomized to high-intensity interval aerob...

Chronic metabolic diseases develop from the complex interaction of environmental and genetic factors, although the extent to which each contributes to these disorders is unknown. Here, we test the hypothesis that artificial selection for low intrinsic aerobic running capacity is associated with reduced skeletal muscle metabolism and impaired metabolic health. Rat models for low- (LCR) and high-...

Introduction: The appropriate physiological response to an acute bout of progressive aerobic exercise requires proper functioning of the pulmonary, cardiovascular and skeletal muscle systems. Unfortunately, these systems are all negatively impacted in patients with heart failure (HF), resulting in signifi cantly diminished aerobic capacity compared with apparently healthy individuals. Cardiopul...

OBJECTIVE To explore whether low aerobic capacity and physical activity are associated with fatigue, when controlling for age, gender, pain and depressive symptoms in persons with rheumatoid arthritis. METHODS In 60 individuals fatigue (Multidimensional Assessment of Fatigue scale; MAF), disease activity (Disease Activity Score-28; DAS 28), pain, physical and psychological status (Arthritis I...

This study presents a description of aerobic capacity in a large US population comprised of 1,514 men and 375 women. Such influencing factors as age, training state, occupation, and body composition were evaluated. The population consisted of new recruits entering the US Army from civilian life as well as soliders in a variety of assignments and physical training programs. Age ranged from 17 to...

An endurance treadmill exercise test protocol of two minute stages of increasing speed and gradient has been designed and evaluated for children under 10 years of age. There was a significant relation between test protocol time and oxygen uptake measured in ml/kg/min in tests performed on 20 subjects. One hundred and sixty exercise tests performed in a semi longitudinal study of healthy primary...