Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Aim: In this study, the role of fine needle aspiration biopsy (FNAB) evaluated with Bethesda System in diagnosis thyroid nodules was investigated. Materials and Methods: Total 2284 FNAB materials 1846 patients were performed Pathology Department Kutahya Health Sciences University, Evliya Celebi Traning Research Hospital between 2016 2019 reported according to category. Among these cases, diagno...

Los enormes avances en la formación de las mujeres y su interés por participar manera continua el mercado laboral podrían hacer pensar una pronta desaparición tradicionales desigualdades entre hombres pero lo cierto es que no ha ocurrido así. Es decir, espectacular transformación oferta femenina se traducido mejora equivalente del lugar ocupan dentro mercado. que, si miran uno a los difer...

©2002 British Editorial Society of Bone and Joint Surgery 0301-620X/02/813447 $2.00 e describe 88 knees (79 patients) with lateral unicompartmental osteoarthritis which had been treated by the St Georg Sled prosthesis. At a mean follow-up of nine years (2 to 21) 15 knees had revision surgery, nine for progression of arthritis, six for loosening, four for breakage of a component and four for mor...

In 1989 the British Journal of Radiology published a review proposing the term biologically effective dose (BED), based on linear quadratic cell survival in radiobiology. It aimed to indicate quantitatively the biological effect of any radiotherapy treatment, taking account of changes in dose-per-fraction or dose rate, total dose and (the new factor) overall time. How has it done so far? Accept...