The plasma-based aerosol process developed for the direct coating of particles in gases with silicon oxide in a continuous chemical vapor deposition (CVD) process is presented. It is shown that non-thermal plasma filaments induced in a dielectric barrier discharge (DBD) at atmospheric pressure trigger post-DBD gas phase reactions. DBD operating conditions are first scanned to produce ozone and ...

Felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to BCS class II category. Hence, its low water solubility limits the pharmacological effect. The aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

The drag force on aggregates and partially sintered agglomerates is assessed using the lattice Boltzmann method (LBM) and accelerated Stokesian dynamics (ASD). Both methods have been compared in terms of accuracy and computational effort. It is shown that they give comparable results if all numerical parameters are controlled carefully. LBM requires a much higher computational effort, however, ...

Some experimental observations on the fluidization characteristics of nanoparticles in the form of agglomerates with magnetic assistance are presented. The nanoagglomerates consist of Degussa Aerosil R974 fumed silica, with a primary particle size of 12 nm. An oscillating AC magnetic field is used to excite large (mm size) permanent magnetic particles mixed in with the nanoparticle agglomerates...

A simple method for analyzing masses of water suspended fullerenes (nC60) in Daphnia magna by extracting to toluene and measuring by ultraviolet-vis spectrophotometry was developed. This method was used to assess bioaccumulation and depuration rates by daphnia after nC60 exposure in artificial freshwater. Accumulation was rapid during the first few hours, and based on accumulation modeling, 90%...

The purpose of this study was to examine the ul trastructural relationships of cholesterol crystals and apatite deposits in human atherosclerotic lesions. Segments of human aortic atherosclerotic lesions were obtained at autopsy , fixed in gl utaraldehyde and dehydrated without using any organic solvents. The aortic segments were coated with carbon and subjected to various scan ning electron mi...

Context. Following the recent insight in the material structure of comets, protoplanetesimals are assumed to have low densities and to be highly porous agglomerates. It is still unclear if planetesimals can be formed from these objects by collisional growth. Aims. Therefore, it is important to study numerically the collisional outcome from low velocity impacts of equal sized porous agglomerates...

Purpose: The quasi-emulsion solvent diffusion (QESD) has evolved into an effective technique to manufacture agglomerates of API crystals. Although, the proposed technique showed benefits, such as cost effectiveness, that is considerably sensitive to the choice of a stabilizer, which agonizes from a absence of systemic understanding in this field. In the present study, the combination of differe...

Understanding the delivered cellular dose of nanoparticles is imperative in nanomedicine and nanosafety, yet is known to be extremely complex because of multiple interactions between nanoparticles, their environment, and the cells. Here, we use 3-D reconstruction of agglomerates preserved by cryogenic snapshot sampling and imaged by electron microscopy to quantify the "bioavailable dose" that i...