A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...

This paper describes a layered architecture representing knowledge to be used for navigation in environments where distinctive places are present. Each knowledge layer defines an abstraction of the environment aimed at efficiently supporting the execution of specific navigation tasks. Layers are structured in a taxonomy, each layer being derived from another by applying one of the three abstrac...

Ubiquitin-positive inclusion containing Fused in Sarcoma (FUS) defines a new subtype of frontotemporal lobar degeneration (FTLD). FTLD is characterized by progressive alteration in cognitions and it preferentially affects the superficial layers of frontotemporal cortex. Mutation of FUS is linked to amyotrophic lateral sclerosis and to motor neuron disease with FTLD. To examine FUS pathology in ...

Energy preservation is one of the most important challenges in wireless sensor networks. In most applications, sensor networks consist of hundreds or thousands nodes that are dispersed in a wide field. Hierarchical architectures and data aggregation methods are increasingly gaining more popularity in such large-scale networks. In this paper, we propose a novel adaptive Energy-Efficient Multi-la...

There exist in the literature today many contributions dealing with the incorporation of fuzzy logic in expert systems. However, unfortunately, much of what has been proposed can only be applied to small-scale expert systems; that is, when the number of rules is in the dozens as opposed to in the hundreds. The more traditional (nonfuzzy) expert systems are able to cope with large numbers of rul...

Solar cells are devices that convert light energy into electricity. To drive greater adoption of solar cell technologies, higher cell efficiencies and reductions in manufacturing cost are necessary. Fluorogens containing rotor structures may be helpful in addressing some of these challenges due to their unique twisted structures and photophysics. In this review, we discuss the applications of r...

We study the aggregation of peptides using the discrete molecular dynamics simulations. Specifically, at temperatures above the alpha-helix melting temperature of a single peptide, the model peptides aggregate into a multilayer parallel beta-sheet structure. This structure has an interstrand distance of 4.8 A and an intersheet distance of 10 A, which agree with experimental observations. Our mo...

We address the issue of the reducibility of the dynamics on a multilayer network to an equivalent process on an aggregated single-layer network. As a typical example of models for opinion formation in social networks, we implement the voter model on a two-layer multiplex network, and we study its dynamics as a function of two control parameters, namely the fraction of edges simultaneously exist...

Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano- and atomic architectures that give the final composite material exceptional mechanical strength and optical iridescence on the macroscale. This multiscale biological assembly inspires new synthetic routes to complex materials. Our investigation of the prism-nacre interface reveals nanoscale deta...

With the rapidly growing amounts of information, visualization is becoming increasingly important, as it allows users to easily explore and understand large amounts of information. However the field of information visualization currently lacks sufficient theoretical foundations. This article addresses foundational questions connecting information visualization with computing and philosophy stud...