Huntington's disease is a fatal autosomal genetic disorder characterized by an expanded glutamine-coding CAG repeat sequence in the huntingtin (Htt) exon 1 gene. The Htt protein associated with the disease misfolds into toxic oligomers and aggregate fibril structures. Competing models for the misfolding and aggregation phenomena have suggested the role of the Htt-N-terminal region and the CAG t...

The VLA-4 (CD49d/CD29) integrin is the only member of the VLA family expressed by resting lymphoid cells that has been involved in cell-cell adhesive interactions. We here describe the triggering of homotypic cell aggregation of peripheral blood T lymphocytes and myelomonocytic cells by mAbs specific for certain epitopes of the human VLA alpha 4 subunit. This anti-VLA-4-induced cell adhesion is...

protein aggregation is a problem in biotechnology. high temperature is one of the most important reasons to enhance enzyme inactivation and aggregation in industrial systems. this work focuses on the effect of tio2 and sio2 nanoparticles on refolding and reactivation of lysozyme. in the presence of tio2 and sio2 nanoparticles, after enzyme heat treatment at 98◦c for 30 min, not only aggregates ...

objective: to study the mechanisms involved in amyloid formation processes, we made a mammalian cell culture model of amylin aggregation and characterized its properties. materials and methods: amyloid fibrils were extracted from cho cells and binding affinity to thioflavin t and congo red was investigated. then the apple-green birefringence of extracted fibrils was detected under polarized li...

The understanding of complex environmental phenomena, such as deforestation and epidemics, requires observations at multiple scales. This scale dependency is not handled well by today’s rather technical sensor definitions. Geosensor networks are normally defined as distributed ad-hoc wireless networks of computing platforms serving to monitor phenomena in geographic space. Such definitions also...

Much of the data consumed today is dynamic, typically gathered from distributed sources including sensors, and used in real-time monitoring and decision making applications. Large scale sensor networks are being deployed for applications such as detecting leakage of hazardous material, tracking forest fires or environmental monitoring. Many of these “natural” phenomena require estimation of the...

This work presents a systematic study of asphaltene pre-aggregation phenomena in the absence and presence ionic liquids (ILs) from family 1-alkyl-3-methylimidazolium by molecular dynamics simulations. The effects alkyl chain length cation (studying ILs with chains between C4 C10) dimension anion (testing chloride bromide) on aggregation behavior asphaltenes have been studied. To correlate resul...

In recent years, a great deal of research has been devoted to wireless sensor networks (WSNs). WSNs are networks consisting of small self-powered devices that communicate with each other over the wireless medium and coordinate their operation in order to perform distributed sensing near physical phenomena. The total lifetime of the network is a major design factor for protocols, applications an...

– A simple sticking probability model is used for deducing a kernel capable to describe the kinetics of computer-simulated irreversible aggregation processes. Not only the diffusionand reaction-limited aggregation regimes were fitted but also the whole transition region. The deduced kernel establishes λ = 0 for the entire range of sticking probabilities and helps to understand how irreversible ...