The Hedgehog (Hh) signaling pathway regulates normal development and cell proliferation in metazoan organisms, but its aberrant activation can promote tumorigenesis. Hh-induced tumors arise from various tissues and they may be indolent or aggressive, as is the case with skin basal cell carcinoma (BCC) or cerebellar medulloblastoma, respectively. Little is known about common cell-intrinsic facto...

BACKGROUND Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of two CSC markers, CD133 and Nestin, in a series of skin tumors. MATERIALS AND METHODS One hundred and thirteen paraffin blocks from skin cancers inc...

The Hedgehog (Hh) signaling pathway regulates normal development and cell proliferation in metazoan organisms, but its aberrant activation can promote tumorigenesis. Hh-induced tumors arise from various tissues and they may be indolent or aggressive, as is the case with skin basal cell carcinoma (BCC) or cerebellar medulloblastoma, respectively. Little is known about common cell-intrinsic facto...

BACKGROUND Basal cell carcinoma (BCC) greater than 5 cm in diameter is called giant basal cell carcinoma (GBCC), or super giant basal cell carcinoma if it has a diameter larger than 20 cm. Giant BCC only accounts for 0.5% of BCCs and super giant BCC is exceedingly rare. On account of their rarity, there are no established guidelines for GBCC treatment. CASE REPORT We describe a peculiar case of...

Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and their number is still increasing worldwide. Furthermore, immunosuppression in organ transplant patients strongly contributes to the increase in skin cancer incidence--being 65-250 times more frequent than in the general population. Often these patients suffer from a secon...

Non-melanoma skin cancer, i.e. basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) are the most frequent tumors and their number is still increasing worldwide [1]. Furthermore, immunosuppression in organ transplant patients strongly contributes to the increase in skin cancer incidence being 65 to 250 times more frequent than in the general population. Often these patients suffer from...

Intracellular bacteria are characterized by genome reduction. The 422,434-base pair genome of Buchnera aphidicola BCc, primary endosymbiont of the aphid Cinara cedri, is approximately 200 kilobases smaller than the previously sequenced B. aphidicola genomes. B. aphidicola BCc has lost most metabolic functions, including the ability to synthesize the essential amino acid tryptophan and riboflavi...

BACKGROUND Arborizing vessels (AVs) are dermoscopically defined as telangiectasias with distinct treelike branching, and are a characteristic feature of basal cell carcinoma (BCC). However, AVs are observed in various conditions other than BCC. OBJECTIVE The aim of this study was to investigate skin diseases showing AV and investigates dermoscopic differences between BCC and non-BCC. METHOD...

Introduction. Basal cell carcinoma is the most common tumour of eyelids and periocular region throughout world. BCC represents 90 % malignant tumours eyelids, predominantly in male population. The incidence higher age over 60. Over 50% initially occur on lower lid inner angle. Research objectives. Literature review epidemiology, aetiopathogenesis, clinical attributes, diagnostics, treatment his...

The concept of fuzzy multiply positive BCC-ideals of BCC-algebras is introduced, and then some related results are obtained. Moreover, we introduce the concept of T -fuzzy multiply positive implicative BCC-ideals of BCC-algebras and investigate T -product of T -fuzzy multiply positive implicative BCC-ideals of BCC-algebras, examining its properties. Using a t-norm T , the direct product and T -...