Isolated basilar artery stenosis (BAS) is a rare etiology of ischemic neurologic conditions. First-line treatment symptomatic typically medical therapy as outlined in the Warfarin–Aspirin Symptomatic Intracranial Disease (WASID) trial and Stenting versus Aggressive Medical Therapy for Arterial Stenosis (SAMMPRIS) trial.1,2 We present case male his 60s with isolated BAS who failed maximal but ex...

Childhood nephrotic syndrome, in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-res...

sinonasal teratocarcinosarcoma (sntcs) is a rare tumor characterized by mixture architecture of epithelial and mesenchymal components. sntcs is a highly malignant tumor displaying progressive and aggressive growth with poor prognosis. only about 40% of all patients survive after five years. it seems the combination of surgery and radiotherapy currently is the most effective treatment. in this r...

the management of carotid artery stenosis reduces the risk of stroke and its related deaths.   management options include risk factor modification and medical therapy, carotid endarterectomy (cea), and carotid artery stenting (cas). although several randomized controlled trials (rcts), mostly conducted in late-1980s and mid-1990s, have proved cea to be effective in the prevention of ipsilateral...

STUDY OBJECTIVE To determine physicians' anticoagulation preferences in patients with a mechanical heart valve who are undergoing elective surgery, and to determine the effect of different risks of thromboembolism (TE) and postoperative bleeding on anticoagulation preferences. DESIGN Mail survey of physicians who prescribe anticoagulant therapy. METHODS AND RESULTS Physicians were asked to ...

background: the success of combined periodontal and orthodontic approach in the treatment of aggressive periodontitis patients with the pathologic extruded anterior teeth is a main concern and stability of the treatment results is an important factor to evaluate the treatment. the present study investigated the periodontal parameters at the end of the orthodontic treatment in patients with the ...

two basic and clinical researches accomplished during the recent years on embryonic and adult stem cells constituted a mutation in regenerative therapy. these cells can be used for treating some degenerative diseases. between them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, parkinson’s and alzheimer’s diseases, ar...

primitive neuroectodermal tumors of the kidney are rare tumors representing about 1% of all sarcomas. extraskeletal primitive neuroectodermal tumors may be found in the genitourinary tract, the testes, ovaries, uterus, or pancreas. renal primitive neuroec- todermal tumors are frequently aggressive and almost 30% of all newly diagnosed cases present with distant metastases. surgical intervention...

Patients with locally advanced renal cell carcinoma are at high risk of metastatic relapse following surgery. Patients with metastatic disease have a poor prognosis and few systemic therapy options. Radiation, chemotherapy, hormonal therapy, vaccines, and immunotherapy have all been tested as adjuvant therapy without benefit. Neoadjuvant therapy in the metastatic setting holds promise as a new ...