A 42-year-old gravida 5 para 3 woman delivered a male newborn at 36 weeks of gestation. She had no significant medical problems and her previous pregnancies led to healthy newborns. The current pregnancy was uneventful and the baby appeared healthy (body weight, 3190 g; Apgar score, 8/10/10). On the second day of life jaundice appeared. Laboratory tests revealed hyperbilirubinemia (total biliru...

An attempt has been made to detect antibodies to aminopyrine or its derivatives ( pyrazolone derivatives) with a passive hemagglutination assay system. Formalinized red blood cells were sensitized by coupling diazotized 4-aminoantipyrine to the surface membrane. With this method, circulating antibodies were detected in a patient with aminopyrine-induced agranulocytosis. Serial determinations re...

Many marketed pharmaceuticals are known to cause idiosyncratic agranulocytosis in humans. Similarly prinomide, an antiinflammatory drug, was associated with a low incidence of agranulocytosis (<0.3%) in clinical trials, even though chronic toxicity studies in rodents and primates showed no evidence of agranulocytosis with either prinomide or its parahydroxy metabolite, CGS 12094. To investigate...

In 1956 Kostmann reported a new disease of infancy which he termed 'infantile genetic agranulocytosis'. He described 14 children of both sexes in nine families. All but two of the children died as a result of the disease. For six of them detailed clinical and histological data were reported. The disease occurs during early infancy with infections particularly of the skin. There is a complete or...