Despite intensive study of p53, the regulation of p53 cellular localization is still poorly understood. This is an overview of the elements and molecules involved in p53 nucleocytoplasmic transportation. These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2-mediated p53 nuclear export, and possible roles of p53 phosphory...

AIMS During cardiac hypertrophy, cardiomyocytes (CMs) increase in the size and expression of cytoskeletal proteins while reactivating a foetal gene programme. The process is proposed to be dependent on increased nuclear export and, since nuclear pore trafficking has limited capacity, a linked decrease in import. Our objective was to investigate the role of nuclear import and export in control o...

nowadays, agricultural r&d provides new and developed technologies to create modern agricultural producing methods. during recent years, improving agricultural productivity is affected by not only domestic r&d investments but also foreign countries r&d investments. nowadays, according to new growth models, r&d is the base of productivity. recent economic theories consider agricu...

This paper examines the environmental-economic cycle for nitrogen in Denmark based on nitrogen input and output from different economic sectors. An input-output model is employed together with a nitrogen mass balance to apportion total nitrogen loading by final demand and estimate export and import of nitrogen from foreign trade. The changes in agricultural and industrial nitrogen loading from ...

khorasan razavi province with the total precipitations of less than 225 mm/year and total area of irrigated area of 1087466 hectare is considered as one of the most important agricultural region in iran. this province has also important role in local and national economy. lack of perennial river and little amount of surface water has caused 1.06 billion cubic meter of over withdrawn from ground...

Effects of increasing sink-source ratio on rate of translocation and net carbon exchange were studied by darkening all but one source leaf of Beta vulgaris L. or one primary leaf of Phaseolus vulgaris L. Rates of export of labeled material and patterns of its distribution among sinks were studied by means of GM detectors. Changes in export and import rates were compared with adjustments in star...

We examine the importance of a firm‟s R and D activity, technology import and intra-sectoral R and D spillovers on the decision to export and export intensity using firm level panel data for the Indian automobile sector from 2000-2014. R and D and technology import activities are found to be important determinants of export activity. There is evidence that R and D spillovers exert positive effe...

Nuclear transport is an energy-dependent process mediated by saturable receptors. Import and export receptors are thought to recognize and bind to nuclear localization signals or nuclear export signals, respectively, in the transported molecules. The receptor-substrate interaction can be direct or mediated by an additional adapter protein. The transport receptors dock their cargoes to the nucle...

Cytochrome b2 reaches the intermembrane space of mitochondria by transport into the matrix followed by export across the inner membrane. While in the matrix, the protein interacts with hsp60, which arrests its folding prior to export. The bacterial-type export sequence in pre-cytochrome b2 functions by inhibiting the ATP-dependent release of the protein from hsp60. Release for export apparently...

a r t i c l e i n f o The current literature suggests that tariff escalation (TE) lowers the competitiveness of processing sectors. Coffee and cotton are agricultural products that face the problem of TE in developing countries, where we observe low global coffee product export shares but high global cotton textile export shares, posing a question on TE's impact on competitiveness. This paper e...