Importance Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. Objective To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection. Design, Setting, and Participants The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, l...

Three new one-dimensional (1D) All-In-One (AIO) type CuI-based hybrid semiconductors with both dative and ionic bonds between the inorganic organic components have been successfully designed synthesized by using ligands containing cationic center coordination available sites. Structural analysis confirms that all compounds share same formula of Cu4I6(L)2 (L ?= ?ligand) are composed 1D-Cu4I62? a...

BACKGROUND Capecitabine and irinotecan combination therapy (XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer (mCRC). Recently, in the Association of Medical Oncology of the German Cancer Society (AIO) 0604 trial, tri-weekly XELIRI plus bevacizumab, with reduced doses of irinotecan (200 mg/m2 on day 1) and capecitabine (1600 mg/m2 on days 1-14), repeated eve...

Les mØthodes d’extraction automatique de termes utilisent couramment des patrons dØcrivant la structure des termes (Ibekwe-Sanjuan et Sanjuan, 2004; Enguehard, 1992; Vergne, 2005). Dans les domaines scienti ques ou techniques comme la mØdecine (Namer, 2005), de nombreux termes appartiennent au vocabulaire savant et sont construits à partir de formants classiques grecs ou latins situØs en dØbut ...

27 Levine M, Walter S, Lee H, Haines T, Holbrook A, Moyer V. Users' guides to the medical literature. IV. How to use an article about harm. J7AMA 1994;271:1615-9. 28 Laupacis A, Welss G, Richardson WS, Tugwell P. Users' guides to the medical literature. V. How to use an article about prognosis. JAMA 1994;272:234-7. 29 Oxman AD, Cook DJ, Guyatt G. Users' guides to the medical literature. VI. How...

3516 Background: CAO/ARO/AIO-94 was published in 2004 with a median follow-up of 46 months (Sauer et al., N Engl J Med 2004). This trial established preoperative CRT as standard treatment for rectal cancer based on an improved local control rate at 5 years, however, no survival benefit could be shown. We here report results with a median follow-up of 134 months. METHODS We randomly assigned 8...